Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | RECQL | P46063 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7676895 | 0.82 | RAB9A (0.48) | ALDH1A1RECQLCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL11531240 | 0.81 | TSHR (0.53) | ALDH1A1RECQLCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL11531019 | 0.80 | ALDH1A1 (0.44) | ALDH1A1RECQLCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL11529058 | 0.79 | LPO (0.39) | ALDH1A1KDM4ESMN1; SMN2MAPTHPGD | |
| SCHEMBL867896 | 0.79 | ALDH1A1 (0.53) | ALDH1A1RECQLCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL14828743 | 0.79 | ALDH1A1 (0.53) | ALDH1A1RECQLCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL9542507 | 0.78 | CYP2C19 (0.47) | ALDH1A1RECQLCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL28630338 | 0.78 | ALDH1A1 (0.52) | ALDH1A1RECQLCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL18512317 | 0.77 | ALDH1A1 (0.44) | ALDH1A1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL29020269 | 0.77 | ALDH1A1 (0.60) | ALDH1A1RECQLCYP1A2CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0010553-B1 | PROCESS OF REDUCING A LOWERALKYL 1-LOWERALKYL-PYRROLE-2-GLYOXYLATE TO A LOWERALKYL 1-LOWERALKYL-PYRROLE-2-ACETATE | McNeilab, Inc. (US) | 1983-05-18 | — | — | EP | claimed |
| US-4255335-A | Preparation of 5-aroyl-1-loweralkylpyrrole-2-acetic acid derivatives | MCNEILAB, INC. (US) | 1981-03-10 | — | — | US | claimed |
| EP-0010553-A1 | Process of reducing a loweralkyl 1-loweralkyl-pyrrole-2-glyoxylate to a loweralkyl 1-loweralkyl-pyrrole-2-acetate | McNeilab, Inc. (US) | 1980-05-14 | — | — | EP | claimed |
| US-4187230-A | Preparation of 5-aroyl-pyrrole compounds | ETHYL CORPORATION (US) | 1980-02-05 | — | — | US | claimed |
| US-4125537-A | REDUCTION OF PYRROLE-2-GLYOXYLATES AMINE CATALYZED ACTION OF HYDROGEN SULFIDE IN TERTIARY AMINE SOLVENT | MCNEIL LABORATORIES, INCORPORATED (US) | 1978-11-14 | — | — | US | claimed |
| US-11833162-B2 | Macrocyclic derivatives, process for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2023-12-05 | — | — | US | disclosed |
| EP-3700911-B1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2023-09-06 | — | — | EP | disclosed |
| CN-111511750-B | Macrocyclic derivatives, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2023-06-13 | — | — | CN | disclosed |
| US-9709907-B2 | Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus | CANON KABUSHIKI KAISHA (JP) | 2017-07-18 | — | — | US | disclosed |
| US-9709907-B2 | Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus | CANON KABUSHIKI KAISHA (JP) | 2017-07-18 | — | — | US | disclosed |
| US-9540338-B2 | Substituted cinnamic acid amides for treating pain | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2017-01-10 | — | — | US | disclosed |
| US-9500966-B2 | Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus | CANON KABUSHIKI KAISHA (JP) | 2016-11-22 | — | — | US | disclosed |
| EP-0010553-A1 | Process of reducing a loweralkyl 1-loweralkyl-pyrrole-2-glyoxylate to a loweralkyl 1-loweralkyl-pyrrole-2-acetate | McNeilab, Inc. (US) | 1980-05-14 | — | — | EP | disclosed |
| US-4187230-A | Preparation of 5-aroyl-pyrrole compounds | ETHYL CORPORATION (US) | 1980-02-05 | — | — | US | disclosed |
| US-4136097-A | COPPER(II) COMPLEX AS PROMOTER | MCNEIL LABORATORIES, INC. (US) | 1979-01-23 | — | — | US | disclosed |
| US-4125537-A | REDUCTION OF PYRROLE-2-GLYOXYLATES AMINE CATALYZED ACTION OF HYDROGEN SULFIDE IN TERTIARY AMINE SOLVENT | MCNEIL LABORATORIES, INCORPORATED (US) | 1978-11-14 | — | — | US | disclosed |
| US-4119639-A | Preparation of 5-aroylpyrrole-2-acetic acid derivatives | MCNEIL LABORATORIES, INCORPORATED (US) | 1978-10-10 | — | — | US | disclosed |
| US-3957818-A | PREPARATION OF PYRROLE-2-ACETIC ACID DERIVATIVES | MCNEIL LABORATORIES, INCORPORATED (US) | 1976-05-18 | — | — | US | disclosed |
| US-3952012-A | MULTISTAGE | MCNEIL LABORATORIES, INCORPORATED (US) | 1976-04-20 | — | — | US | disclosed |
| US-3950355-A | 5-CHLOROCARBONYL | MCNEIL LABORATORIES, INC. (US) | 1976-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11833162-B2 | Macrocyclic derivatives, process for preparing same and pharmaceutical compositions containing same | C1R, F12, RDX | ALDH1A1 1066/4885RECQL 21/4885CYP1A2 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.