Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | ITGAV | P06756 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757908 | 0.86 | ITGB3 (0.42) | GAAITGB3ITGA2BITGAVTP53 | |
| SCHEMBL687571 | 0.85 | ALDH1A1 (0.50) | ITGB3ITGA2BITGAVTP53SMN1; SMN2 | |
| SCHEMBL687727 | 0.83 | POLB (0.44) | ITGB3ITGA2BITGAVNPC1TP53 | |
| SCHEMBL687428 | 0.83 | PTGER3 (0.56) | ITGB3ITGAVRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL687886 | 0.83 | PTGER3 (0.56) | ITGB3ITGAVRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL688223 | 0.82 | PTGER3 (0.55) | GAACASP1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL687922 | 0.82 | PTGER3 (0.50) | GAATP53KMT2A | |
| SCHEMBL695420 | 0.82 | MAPT (0.54) | ITGB3ITGA2BTP53SMN1; SMN2KMT2A | |
| SCHEMBL688325 | 0.82 | ALDH1A1 (0.51) | ITGB3ITGA2BITGAVTP53SMN1; SMN2 | |
| SCHEMBL687253 | 0.82 | ITGB3 (0.44) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |