Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 12/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.43 |
| ▸ | ITGAV | P06756 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687812 | 0.92 | POLB (0.45) | POLBHPGDITGB3ITGA2BITGAV | |
| SCHEMBL687571 | 0.83 | ALDH1A1 (0.50) | POLBHPGDITGB3ITGA2BITGAV | |
| SCHEMBL687749 | 0.83 | GAA (0.48) | ITGB3ITGA2BITGAVNPC1RAB9A | |
| SCHEMBL14303532 | 0.83 | POLB (0.48) | POLBHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4757908 | 0.82 | ITGB3 (0.42) | ITGB3ITGA2BITGAVTP53 | |
| SCHEMBL687728 | 0.82 | ITGB3 (0.41) | ITGB3ITGA2BITGAVRAB9A | |
| SCHEMBL13120840 | 0.81 | POLB (0.43) | POLBHPGDITGB3ITGA2BNPC1 | |
| SCHEMBL695420 | 0.81 | MAPT (0.54) | POLBHPGDITGB3ITGA2BSMN1; SMN2 | |
| SCHEMBL687253 | 0.81 | ITGB3 (0.44) | HPGDITGB3ITGA2BITGAV | |
| SCHEMBL688325 | 0.81 | ALDH1A1 (0.51) | POLBHPGDITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |