Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877493 | 1.00 | TP53 (0.49) | TP53MCHR1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL6463465 | 0.91 | MCHR1 (0.44) | TP53MCHR1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL6463450 | 0.91 | MCHR1 (0.44) | TP53MCHR1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL6877916 | 0.90 | KMT2A (0.53) | TP53MCHR1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL6877910 | 0.90 | KMT2A (0.53) | TP53MCHR1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL6872148 | 0.88 | ALDH1A1 (0.55) | MCHR1SMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL6872143 | 0.88 | ALDH1A1 (0.55) | MCHR1SMN1; SMN2KMT2AMEN1KDM4E | |
| SCHEMBL6878770 | 0.88 | ALDH1A1 (0.45) | TP53MCHR1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6878768 | 0.88 | ALDH1A1 (0.45) | TP53MCHR1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6873560 | 0.86 | LMNA (0.56) | MCHR1MAPTSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |