Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.50 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | CCNK | O75909 | 2/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.44 |
| ▸ | CDK7 | P50613 | 2/20 | 0.44 |
| ▸ | CCNH | P51946 | 2/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.44 |
| ▸ | JUN | P05412 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877984 | 0.89 | MAPK8 (0.49) | LMNAHTTKMT2AOPRM1OPRL1 | |
| SCHEMBL6877981 | 0.89 | MAPK8 (0.49) | LMNAHTTKMT2AOPRM1OPRL1 | |
| SCHEMBL6462830 | 0.87 | ADRA2A (0.43) | LMNAHTTKMT2AOPRM1OPRL1 | |
| SCHEMBL6462237 | 0.87 | HTT (0.52) | HTTKMT2AMAPK8MAPK9HTR1A | |
| SCHEMBL6460015 | 0.87 | HTT (0.52) | HTTKMT2AMAPK8MAPK9HTR1A | |
| SCHEMBL6868965 | 0.87 | ADRA2A (0.43) | LMNAHTTKMT2AOPRM1OPRL1 | |
| SCHEMBL6875163 | 0.85 | EIF2AK2 (0.46) | LMNAKMT2AHTR1AALDH1A1 | |
| SCHEMBL6875158 | 0.85 | EIF2AK2 (0.46) | LMNAKMT2AHTR1AALDH1A1 | |
| SCHEMBL6867978 | 0.83 | ADRA2A (0.42) | KMT2AMAPK8MAPK9MAPK10ADRA2A | |
| SCHEMBL6867944 | 0.83 | ADRA2A (0.42) | KMT2AMAPK8MAPK9MAPK10ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |