SCHEMBL6878007

SCHEMBL6878007

O=C1C=C(C(C2=CC(=O)NC2=O)(c2ccccc2)c2ccccc2)C(=O)N1

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.33
TSHR P16473 2/20 0.30
KCNN4 O15554 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11384212 0.73 CYP1A2 (0.33) TSHR
SCHEMBL4356684 0.67 ALDH1A1 (0.40) ALDH1A1
SCHEMBL11722468 0.67 POLB (0.31)
SCHEMBL27737312 0.67 GSK3B (0.37) GSK3BKCNN4ALDH1A1
SCHEMBL3470185 0.66
Ethylene SCHEMBL27950511 0.65 BACE1 (0.43) GSK3BALDH1A1
Benzene SCHEMBL28483360 0.64 GSK3B (0.31) GSK3B
Benzene SCHEMBL27617257 0.64 GSK3B (0.31) GSK3B
SCHEMBL2211488 0.64 POLB (0.41) GSK3BTSHRALDH1A1
SCHEMBL41940 0.64 BACE1 (0.46) GSK3BALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6812311-B2 APPLYING PRECURSORS HAVING ETHYLNYL GROUP; CROSSLINKER AND A SOLVENT ONTO A SURFACE TO FORM ELECTRICALLY INSULATING LAYER; REACTING ETHYNYL GROUP WITH REACTIVE GROUP IN CARBON-CARBON BOND FORMING REACTION AND REACTING; CROSSLINKING HONEYWELL INTERNATIONAL INC. 2004-11-02 US disclosed
WO-2001019889-A9 HIGHLY STABLE PACKAGING SUBSTRATES AND BROMINATED INDANE DERIVATIVES ALLIED SIGNAL INC (US) 2002-10-03 WO disclosed
US-20020132053-A1 Highly stable packaging substrates HONEYWELL INTERNATIONAL, INC. 2002-09-19 US disclosed
EP-1226201-A1 HIGHLY STABLE PACKAGING SUBSTRATES AND BROMINATED INDANE DERIVATIVES AlliedSignal Inc. (US) 2002-07-31 EP disclosed
US-6346296-B1 ETHYNYL GROUPS ON BACKBONES, CROSSLINKING IN SOLVENTS ALLIEDSIGNAL INC. 2002-02-12 US disclosed
WO-2001019889-A1 HIGHLY STABLE PACKAGING SUBSTRATES AND BROMINATED INDANE DERIVATIVES ALLIEDSIGNAL INC. (US) 2001-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020132053-A1 Highly stable packaging substrates AGO2, EED, SYNJ2 GSK3B 4415/4885TSHR 4850/4885KCNN4 2485/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.