Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 16/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 13/20 | 0.40 |
| ▸ | HRH1 | P35367 | 5/20 | 0.40 |
| ▸ | HTR2B | P41595 | 5/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878270 | 1.00 | ALDH1A1 (0.53) | ALDH1A1HPGDGFERMAPTALOX15 | |
| SCHEMBL27652861 | 0.85 | HPGD (0.50) | ALDH1A1HPGDHSD17B10RAB9AMCHR1 | |
| SCHEMBL27652859 | 0.85 | HPGD (0.50) | ALDH1A1HPGDHSD17B10RAB9AMCHR1 | |
| SCHEMBL6878339 | 0.84 | MCHR1 (0.41) | HPGDMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6878333 | 0.84 | MCHR1 (0.41) | HPGDMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6879288 | 0.83 | EPHX1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6879285 | 0.83 | EPHX1 (0.53) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6872301 | 0.83 | CYP3A4 (0.46) | ALDH1A1MAPTHSD17B10RAB9AMCHR1 | |
| SCHEMBL6872308 | 0.83 | CYP3A4 (0.46) | ALDH1A1MAPTHSD17B10RAB9AMCHR1 | |
| SCHEMBL6878362 | 0.83 | ADAM17 (0.40) | RAB9AMCHR1ADRA2AHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |