Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.58 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.50 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.49 |
| ▸ | ADH5 | P11766 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27943949 | 0.85 | TBXAS1 (0.59) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL21791731 | 0.84 | LMNA (0.62) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL2532397 | 0.83 | LMNA (0.78) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL676457 | 0.82 | LMNA (0.64) | LMNAMAPTENPP2MKNK1MKNK2 | |
| Hydrochloric Acid SCHEMBL28701756 | 0.81 | LMNA (0.75) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL857216 | 0.81 | ENPP2 (0.63) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL22486535 | 0.81 | LMNA (0.58) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL255498 | 0.81 | MAOB (0.62) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL2460217 | 0.81 | NOTUM (0.63) | LMNAMAPTENPP2MKNK1MKNK2 | |
| SCHEMBL1011668 | 0.81 | LMNA (0.63) | LMNAMAPTENPP2MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |