Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880110 | 1.00 | SIGMAR1 (0.48) | SIGMAR1MAPTRXFP1HTR2BHTR2C | |
| SCHEMBL6878072 | 0.89 | NPC1 (0.44) | SIGMAR1MAPTHTR2BHTR2CMCHR1 | |
| SCHEMBL6878067 | 0.89 | NPC1 (0.44) | SIGMAR1MAPTHTR2BHTR2CMCHR1 | |
| SCHEMBL6877589 | 0.87 | EPHX1 (0.53) | MAPTMCHR1EPHX1KDRADRA2A | |
| SCHEMBL6878657 | 0.86 | EPHX1 (0.49) | MCHR1EPHX1ADRA2AS1PR1OPRD1 | |
| SCHEMBL6878665 | 0.86 | EPHX1 (0.49) | MCHR1EPHX1ADRA2AS1PR1OPRD1 | |
| SCHEMBL6880550 | 0.84 | MAPT (0.54) | MAPTMCHR1NPC1KDRADRA2A | |
| SCHEMBL6880545 | 0.84 | MAPT (0.54) | MAPTMCHR1NPC1KDRADRA2A | |
| SCHEMBL6874686 | 0.83 | RAB9A (0.53) | MAPTRXFP1NPC1RAB9AKDM4E | |
| SCHEMBL6873468 | 0.83 | SMN1; SMN2 (0.51) | MAPTNPC1RAB9AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |