Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.47 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1434181 | 0.87 | F7 (0.58) | KDM4ESLC6A4IDO1F7F3 | |
| SCHEMBL3631475 | 0.84 | ALDH1A1 (0.54) | SLC6A4IDO1L3MBTL1F7F3 | |
| SCHEMBL9937045 | 0.84 | NR4A2 (0.65) | SLC6A4LMNARAB9ANR4A2 | |
| SCHEMBL26054532 | 0.84 | L3MBTL1 (0.48) | SLC6A4IDO1L3MBTL1F7F3 | |
| SCHEMBL7464145 | 0.82 | SLC6A4 (0.49) | SLC6A4HTR6HTR1ADRD1SLC6A2 | |
| SCHEMBL20846196 | 0.82 | HTR6 (0.46) | PBRM1KDM4EHSD17B10SLC6A4HTR6 | |
| SCHEMBL12782163 | 0.82 | F7 (0.45) | SLC6A4IDO1F7F3HTR6 | |
| SCHEMBL7386532 | 0.82 | IDO1 (0.43) | SLC6A4IDO1L3MBTL1F7F3 | |
| SCHEMBL8808423 | 0.82 | LMNA (0.62) | SLC6A4IDO1F7F3HTR6 | |
| SCHEMBL2076915 | 0.81 | IDO1 (0.46) | SLC6A4IDO1HTR6HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1155568-C | Method for producing 3-alkanoylindoles and 3-alkylindoles | Ĭ��ר���ɷ�����˾ | 2004-06-30 | — | — | CN | disclosed |
| EP-1140824-B1 | METHOD FOR PRODUCING 3-ALKANOYLINDOLES AND 3-ALKYLINDOLES | MERCK PATENT GMBH (DE) | 2004-05-19 | — | — | EP | disclosed |
| US-6509475-B1 | Friedel-Crafts acylation catalyzed by Lewis acid alkylaluminum dichloride; chemical reduction, salt formation | MERCK PATENT GMBH (DE) | 2003-01-21 | — | — | US | disclosed |
| CN-1330635-A | Method for producing 3-alkanoylindoles and 3-alkylindoles | MERCK PATENT GMBH (DE) | 2002-01-09 | — | — | CN | disclosed |
| EP-1140824-A1 | METHOD FOR PRODUCING 3-ALKANOYLINDOLES AND 3-ALKYLINDOLES | MERCK PATENT GmbH (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035872-A1 | METHOD FOR PRODUCING 3-ALKANOYLINDOLES AND 3-ALKYLINDOLES | MERCK PATENT GMBH (DE) | 2000-06-22 | — | — | WO | disclosed |