Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879419 | 1.00 | MCHR1 (0.46) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6875068 | 0.90 | MCHR1 (0.47) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6875980 | 0.90 | ALOX12 (0.56) | MCHR1ADRA2AHRH1HTR2BHTT | |
| SCHEMBL6875063 | 0.90 | MCHR1 (0.47) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6875977 | 0.90 | ALOX12 (0.56) | MCHR1ADRA2AHRH1HTR2BHTT | |
| SCHEMBL6868667 | 0.90 | ALPL (0.52) | MCHR1ADRA2AHRH1HTR2BHTT | |
| SCHEMBL6868673 | 0.90 | ALPL (0.52) | MCHR1ADRA2AHRH1HTR2BHTT | |
| SCHEMBL7044566 | 0.90 | BCHE (0.46) | MCHR1ADRA2AHTTLMNAPKM | |
| SCHEMBL7044564 | 0.90 | BCHE (0.46) | MCHR1ADRA2AHTTLMNAPKM | |
| SCHEMBL6875251 | 0.90 | MCHR1 (0.50) | MCHR1ADRA2AHRH1HTR2BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |