Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 11/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69442 | 0.84 | ADRB2 (0.38) | ADRB2TSHRHIF1AADRA1AOPRM1 | |
| SCHEMBL11503300 | 0.80 | OPRM1 (0.49) | ADRB2TSHRHIF1AADRA1AOPRM1 | |
| SCHEMBL2952875 | 0.79 | ADRB2 (0.53) | ADRB2TSHRHIF1AADRA1ACYP3A4 | |
| SCHEMBL68774 | 0.78 | ADRB2 (0.54) | ADRB2TSHRHIF1AADRA1ACYP3A4 | |
| SCHEMBL3233268 | 0.77 | ESR1 (0.58) | TSHRHIF1AADRA1AOPRM1LMNA | |
| SCHEMBL11301838 | 0.77 | ADRB2 (0.46) | ADRB2ADRA1AOPRM1SLC22A1LMNA | |
| SCHEMBL11831177 | 0.77 | ADRB2 (0.53) | ADRB2TSHRHIF1AADRA1ACYP3A4 | |
| SCHEMBL2953489 | 0.77 | ADRB2 (0.53) | ADRB2TSHRHIF1AADRA1ACYP3A4 | |
| SCHEMBL11828601 | 0.77 | ADRB2 (0.53) | ADRB2TSHRHIF1AADRA1ACYP3A4 | |
| SCHEMBL69138 | 0.76 | ALOX15 (0.48) | ADRB2TSHRHIF1AADRA1AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258322-B2 | Synthesis of hexahydrodibenzopyranones | WATSON LABORATORIES, INC. (US) | 2012-09-04 | — | — | US | disclosed |
| EP-2479203-A1 | AROMATIC POLYESTER | Muroran Institute of Technology (JP) | 2012-07-25 | — | — | EP | disclosed |
| US-20120172570-A1 | AROMATIC POLYESTER | NITTA CORPORATION | 2012-07-05 | — | — | US | disclosed |
| US-8129493-B2 | Aromatic polyester | MURORAN INSTITUTE OF TECHNOLOGY (JP) | 2012-03-06 | — | — | US | disclosed |
| US-20110224343-A1 | MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME | MURORAN INSTITUTE OF TECHNOLOGY (JP) | 2011-09-15 | — | — | US | disclosed |
| CN-102131795-A | Improved synthesis of hexahydrodibenzopyranones | DALTON CHEMICAL LAB INC | 2011-07-20 | — | — | CN | disclosed |
| EP-2331519-A1 | IMPROVED SYNTHESIS OF HEXAHYDRODIBENZOPYRANONES | Watson Laboratories, Inc. (US) | 2011-06-15 | — | — | EP | disclosed |
| US-20110092662-A1 | AROMATIC POLYESTER | NITTA CORPORATION (JP) | 2011-04-21 | — | — | US | disclosed |
| US-20100056811-A1 | Synthesis of Hexahydrodibenzopyranones | WATSON LABORATORIES, INC. | 2010-03-04 | — | — | US | disclosed |
| WO-2010022520-A1 | IMPROVED SYNTHESIS OF HEXAHYDRODIBENZOPYRANONES | DALTON CHEMICAL LABORATORIES INC. (CA) | 2010-03-04 | — | — | WO | disclosed |
| US-4148809-A | Process for preparing dl-cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones | ELI LILLY AND COMPANY (US) | 1979-04-10 | — | — | US | disclosed |
| US-4088777-A | Hexahydro-dibenzo[b,d]pyran-9-ones as anticonvulsant drugs | ELI LILLY AND COMPANY (US) | 1978-05-09 | — | — | US | disclosed |
| US-4087546-A | Hexahydro-dibenzo[b,d]pyran-9-ones as antiasthmatic drugs | ELI LILLY AND COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4087547-A | Hexahydro-dibenzo[b,d]pyran-9-ones in treatment of glaucoma | ELI LILLY AND COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4087545-A | Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs | ELI LILLY AND COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4024275-A | Method of reducing elevated blood pressure with dihydroxy-hexahydrodibenzo(b,d)pyrans | ELI LILLY AND COMPANY (US) | 1977-05-17 | — | — | US | disclosed |
| US-3987188-A | Hexahydro-dibenzo[b,d]pyran-9-ones as sedative drugs | ELI LILLY AND COMPANY (US) | 1976-10-19 | — | — | US | disclosed |
| US-3968125-A | Dihydroxyhexahydrodibenzo[b,d]pyrans | ELI LILLY AND COMPANY (US) | 1976-07-06 | — | — | US | disclosed |
| US-3953603-A | Hexahydro-dibenzo[b,d,]pyran-9-ones as psychotropic, particularly anti-depressant drugs | ELI LILLY AND COMPANY (US) | 1976-04-27 | — | — | US | disclosed |
| US-3944673-A | Hexahydro-dibenzo[b,d]pyran-9-ones as analgesic drugs | ELI LILLY AND COMPANY (US) | 1976-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224343-A1 | MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME | F12, PHAX, WDR82 | ADRB2 1430/4885TSHR 3263/4885HIF1A 1324/4885 |
| US-20100056811-A1 | Synthesis of Hexahydrodibenzopyranones | GNE, GALE, UGDH | ADRB2 390/4885TSHR 3594/4885HIF1A 3298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.