Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGAV | P06756 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687369 | 0.90 | WDR5 (0.44) | ITGB1ITGA4ITGB3ITGAVKMT2A | |
| SCHEMBL687511 | 0.90 | MEN1 (0.46) | ITGB1ITGA4KMT2AMEN1POLB | |
| SCHEMBL688264 | 0.90 | LCK (0.47) | LMNAKMT2AMEN1POLBLCK | |
| SCHEMBL688082 | 0.89 | TP53 (0.41) | ITGB1ITGA4KMT2AMEN1POLB | |
| SCHEMBL686919 | 0.88 | GAA (0.45) | LMNAITGB1ITGA4KMT2AMEN1 | |
| SCHEMBL687408 | 0.87 | KMT2A (0.43) | LMNAITGB1ITGA4KMT2AMEN1 | |
| SCHEMBL688110 | 0.87 | MEN1 (0.49) | LMNAITGB1ITGA4KMT2AMEN1 | |
| SCHEMBL688084 | 0.86 | CYP26A1 (0.43) | ITGB1ITGA4KMT2AMEN1POLB | |
| SCHEMBL687809 | 0.85 | ITGB1 (0.39) | LMNAITGB1ITGA4TP53 | |
| SCHEMBL688306 | 0.85 | MAPT (0.51) | ITGB1ITGA4ITGB3ITGAVEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |