Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | JAK1 | P23458 | 2/20 | 0.52 |
| ▸ | TYK2 | P29597 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.52 |
| ▸ | KMO | O15229 | 1/20 | 0.51 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | AGXT | P21549 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1535781 | 0.88 | BCAT2 (0.54) | BCAT2POLBHTTHSD17B10PARP1 | |
| SCHEMBL2565236 | 0.86 | BCAT2 (0.56) | LRRK2JAK2JAK1TYK2JAK3 | |
| SCHEMBL27476310 | 0.84 | GRM5 (0.50) | JAK2JAK1TYK2JAK3BCAT2 | |
| SCHEMBL29789681 | 0.81 | AOC3 (0.55) | JAK2LMNAPOLBHTTHSD17B10 | |
| SCHEMBL22410905 | 0.78 | JAK2 (0.48) | JAK2JAK1TYK2JAK3KMO | |
| SCHEMBL22410906 | 0.78 | AKR1C3 (0.54) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL28090800 | 0.77 | BCAT2 (0.64) | BCAT2LMNAPOLBHTTRPS6KB1 | |
| SCHEMBL303084 | 0.77 | KMO (0.77) | LRRK2KMOLMNAHSD17B10PARP1 | |
| SCHEMBL29077217 | 0.77 | LMNA (0.49) | LRRK2KMOLMNAAGXTBRD4 | |
| SCHEMBL10908563 | 0.76 | BCAT2 (0.77) | BCAT2HSD17B10PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1243724-C | Amide derivatives which are useful as cell factor inhibitors | ASTRA ZENECA LTD (SE) | 2006-03-01 | — | — | CN | disclosed |
| US-6821965-B1 | IMPORTANT IN DISEASE OR MEDICAL CONDITIONS SUCH AS INFLAMMATION AND IMMUNOREGULATION | ASTERZENECA AB (SE) | 2004-11-23 | — | — | US | disclosed |