Sugi Predict

Sugi Predict / Compounds / SCHEMBL688116

SCHEMBL688116

SCHEMBL688116

O=c1c(Br)cc(-c2ccccn2)cn1-c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRIA1 P42261 1/20 0.59
▸ GRIA3 P42263 1/20 0.59
▸ PDE4D Q08499 1/20 0.59
▸ POLB P06746 2/20 0.42
▸ GAA P10253 1/20 0.42
▸ TSHR P16473 1/20 0.42
▸ BRD4 O60885 1/20 0.38
▸ CYP2A6 P11509 1/20 0.38
▸ HTR1A P08908 1/20 0.38
▸ HTR7 P34969 1/20 0.38
▸ GRM5 P41594 3/20 0.38
▸ COMT P21964 1/20 0.37
▸ KDM4E B2RXH2 2/20 0.36
▸ LMNA P02545 2/20 0.36
▸ CYP1A2 P05177 1/20 0.36
▸ CCR1 P32246 1/20 0.36
▸ CCR5 P51681 1/20 0.36
▸ CCR8 P51685 1/20 0.36
▸ METAP1 P53582 1/20 0.36
▸ BLM P54132 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1881024 0.89 CYP2A6 (0.51) GRIA1GRIA3PDE4DPOLBGAA
SCHEMBL1881456 0.87 GRIA1 (0.47) GRIA1GRIA3PDE4DPOLBGAA
SCHEMBL1886927 0.86 POLB (0.57) GRIA1GRIA3PDE4DPOLBGAA
SCHEMBL18088206 0.85 GRIA1 (0.69) GRIA1GRIA3PDE4DPOLBGAA
SCHEMBL30577405 0.85 GRIA1 (0.69) GRIA1GRIA3PDE4DPOLBGAA
SCHEMBL1886861 0.85 ABL1 (0.46) GRIA1GRIA3PDE4DPOLBGAA
SCHEMBL1887704 0.84 GRIA1 (0.71) GRIA1GRIA3PDE4DPOLBBRD4
SCHEMBL1882837 0.83 GRIA1 (0.59) GRIA1GRIA3PDE4DPOLBBRD4
SCHEMBL1884948 0.83 GRIA1 (0.70) GRIA1GRIA3PDE4DGAABRD4
SCHEMBL10077186 0.83 GRIA1 (0.59) GRIA1GRIA3PDE4DBRD4CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109799298-B Detection method of related substances in Perampanel bulk drug 南京海纳医药科技股份有限公司 2022-01-07 — — CN claimed
CN-109342603-B Detection method of perampanel tablet related substances 南京海纳医药科技股份有限公司 2020-08-21 — — CN claimed
US-20160039759-A1 PROCESS FOR THE PREPARATION OF PERAMPANEL CADILA HEALTHCARE LIMITED (IN) 2016-02-11 — — US claimed
US-7939549-B2 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof EISAI R&D MANAGEMENT CO., LTD. (JP) 2011-05-10 — — US claimed
CN-118851993-A Method for removing metal impurities in pirenzenenaphthalene 锦州奥鸿药业有限责任公司 2024-10-29 — — CN disclosed
CN-109799298-B Detection method of related substances in Perampanel bulk drug 南京海纳医药科技股份有限公司 2022-01-07 — — CN disclosed
CN-109342603-B Detection method of perampanel tablet related substances 南京海纳医药科技股份有限公司 2020-08-21 — — CN disclosed
CN-110028442-B Simple preparation method of Perampanel 新发药业有限公司 2020-07-17 — — CN disclosed
US-20180008584-A1 PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL MAPI PHARMA LTD. (IL) 2018-01-11 — — US disclosed
EP-3024821-B1 PROCESS FOR THE PREPARATION OF PERAMPANEL TEVA PHARMACEUTICALS INT GMBH (CH) 2017-09-27 — — EP disclosed
US-9695147-B2 Process for the preparation of perampanel TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) 2017-07-04 — — US disclosed
US-9695147-B2 Process for the preparation of perampanel TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) 2017-07-04 — — US disclosed
CN-1738618-A Pharmaceutical compositions and their uses EISAI CO LTD (JP) 2006-02-22 — — CN disclosed
US-20050245581-A1 1, 2-Dihydropyridine compounds, manufacturing method thereof and use thereof EISAI R&D MANAGEMENT CO., LTD. (JP) 2005-11-03 — — US disclosed
US-6949571-B2 1,2-dihydropyridine compounds, process for preparation of the same and use thereof EISAI CO., LTD. (JP) 2005-09-27 — — US disclosed
EP-1465626-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES Eisai Co., Ltd. (JP) 2004-10-13 — — EP disclosed
US-20040023973-A1 1,2-Dihydropyridine compounds, process for preparation of the same and use thereof CATALYST PHARMACEUTICALS, INC. 2004-02-05 — — US disclosed
CN-1436172-A 1, 2-dihydropyridine compound, preparation method and application thereof EISAI CO LTD (JP) 2003-08-13 — — CN disclosed
WO-2003047577-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES EISAI CO LTD (JP) 2003-06-12 — — WO disclosed
EP-1300396-A1 1,2-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF Eisai Co., Ltd. (JP) 2003-04-09 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040023973-A1 1,2-Dihydropyridine compounds, process for preparation of the same and use thereof GRIK1, GRIK2, GRIK4 GRIA1 14/4885GRIA3 58/4885PDE4D 2584/4885
US-20050245581-A1 1, 2-Dihydropyridine compounds, manufacturing method thereof and use thereof GRIK1, GRIK2, GRIK5 GRIA1 24/4885GRIA3 46/4885PDE4D 1607/4885
US-20180008584-A1 PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL PDXK, P2RY1, ADH1A GRIA1 1230/4885GRIA3 1843/4885PDE4D 1383/4885
US-20160039759-A1 PROCESS FOR THE PREPARATION OF PERAMPANEL PNMT, AGPS, OPRM1 GRIA1 997/4885GRIA3 533/4885PDE4D 652/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.