Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 5/20 | 0.50 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6884793 | 0.90 | MMP12 (0.49) | MMP12MMP13ALDH1A1SMN1; SMN2ROCK2 | |
| SCHEMBL8342785 | 0.90 | MMP12 (0.59) | MMP12MMP13ALDH1A1SMN1; SMN2PPID | |
| SCHEMBL8340728 | 0.89 | MMP12 (0.64) | MMP12MMP13ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL6882435 | 0.82 | MMP12 (0.55) | MMP12MMP13ALDH1A1SMN1; SMN2PPID | |
| SCHEMBL6881457 | 0.81 | MMP12 (0.59) | MMP12MMP13ALDH1A1SMN1; SMN2PPID | |
| SCHEMBL6878974 | 0.81 | MMP12 (0.55) | MMP12MMP13ALDH1A1SMN1; SMN2PPID | |
| SCHEMBL6881590 | 0.81 | MMP12 (0.75) | MMP12MMP13SMN1; SMN2PPIDKMT2A | |
| SCHEMBL8342379 | 0.80 | MMP12 (0.57) | MMP12MMP13ALDH1A1SMN1; SMN2PPID | |
| SCHEMBL8338023 | 0.80 | MMP12 (0.57) | MMP12MMP13SMN1; SMN2PPIDKMT2A | |
| SCHEMBL6882405 | 0.79 | MMP12 (0.56) | MMP12MMP13ALDH1A1PPIDPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | WARNER-LAMBERT COMPANY LLC | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | MMP11, MMP13, CBR1 | MMP12 7/4885MMP13 2/4885ALDH1A1 563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.