Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6882200 | 0.89 | MMP12 (0.50) | MMP12SMN1; SMN2EGFRALDH1A1ROCK2 | |
| SCHEMBL6455151 | 0.86 | MMP12 (0.66) | MMP12SMN1; SMN2NR1H4ALDH1A1KMT2A | |
| SCHEMBL8341227 | 0.83 | MMP12 (0.77) | MMP12SMN1; SMN2ALDH1A1MMP13MMP2 | |
| SCHEMBL6450538 | 0.80 | MMP12 (0.69) | MMP12SMN1; SMN2DGAT1EGFRNR1H4 | |
| SCHEMBL6873364 | 0.80 | MMP12 (0.74) | MMP12EGFRNR1H4ROCK2ROCK1 | |
| SCHEMBL6884793 | 0.79 | MMP12 (0.49) | MMP12SMN1; SMN2EGFRNR1H4ALDH1A1 | |
| SCHEMBL6873463 | 0.79 | MMP12 (0.71) | MMP12EGFRNR1H4MMP13MMP2 | |
| SCHEMBL8342785 | 0.79 | MMP12 (0.59) | MMP12SMN1; SMN2EGFRALDH1A1NFKB1 | |
| SCHEMBL6461928 | 0.77 | MMP12 (1.00) | MMP12EGFRNR1H4ALDH1A1GAA | |
| SCHEMBL8339276 | 0.76 | MMP12 (0.75) | MMP12SMN1; SMN2NR1H4ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | disclosed |