Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229548 | 0.79 | PKM (0.37) | TSHRRAPGEF4KDM4EALDH1A1MAPK1 | |
| SCHEMBL7303767 | 0.74 | TSHR (1.00) | TSHRPOLBGAAKDM4EALDH1A1 | |
| SCHEMBL6881906 | 0.73 | TSHR (0.68) | TSHRADORA1ADORA2APOLBGAA | |
| SCHEMBL31194571 | 0.72 | TSHR (0.70) | TSHRPOLBGAAKDM4EALDH1A1 | |
| SCHEMBL1813384 | 0.71 | ALDH1A1 (0.36) | RAPGEF4POLBGAAKDM4EALDH1A1 | |
| SCHEMBL5236933 | 0.71 | ALDH1A1 (0.36) | RAPGEF4POLBGAAKDM4EALDH1A1 | |
| SCHEMBL30928891 | 0.70 | ADORA1 (0.51) | TSHRADORA1ADORA3ADORA2ACYP19A1 | |
| SCHEMBL8123177 | 0.70 | TSHR (0.63) | TSHRADORA1ADORA2APOLBGAA | |
| SCHEMBL8916000 | 0.68 | TSHR (0.67) | TSHRADORA1ADORA2APOLBGAA | |
| SCHEMBL1076537 | 0.68 | TSHR (0.60) | TSHRPOLBGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040241706-A1 | Highly specific modulators of GTPases for target validation | IRM, LLC | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040241706-A1 | Highly specific modulators of GTPases for target validation | CDC42, ARHGDIB, ARHGEF2 | TSHR 3893/4885RAPGEF4 29/4885ADORA1 4727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.