Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.61 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.41 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLUL | P15104 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726591 | 0.86 | FOLH1 (0.57) | FOLH1LMNACYP3A4NFKB1BLM | |
| SCHEMBL10587263 | 0.82 | GABBR2 (0.54) | FOLH1GABRR1LMNABLMGABBR2 | |
| Ammonia Solution, Strong SCHEMBL10491234 | 0.80 | GABBR2 (0.52) | FOLH1GABRR1LMNABLMGABBR2 | |
| SCHEMBL10624719 | 0.80 | FOLH1 (0.67) | FOLH1LMNABLMGLULNAALAD2 | |
| SCHEMBL8674489 | 0.80 | FOLH1 (0.54) | FOLH1LMNABLMGABBR2GABBR1 | |
| SCHEMBL10702069 | 0.78 | FOLH1 (0.64) | FOLH1LMNABLMGLULGRIN2D | |
| SCHEMBL11294536 | 0.78 | FOLH1 (0.64) | FOLH1ALDH1A1GLULNAALAD2 | |
| SCHEMBL9115882 | 0.77 | FOLH1 (0.42) | FOLH1GABRR1LMNACYP3A4NFKB1 | |
| SCHEMBL2905376 | 0.76 | FOLH1 (0.61) | FOLH1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2201753 | 0.76 | FOLH1 (1.00) | FOLH1GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825211-B1 | GLUTAMATE RECEPTORS PLAY A ROLE IN NUMEROUS NEUROLOGICAL, NEURODEGENERATIVE, PSYCHIATRIC, AND PSYCHOLOGICAL DISORDERS | GEORGETOWN UNIVERSITY | 2004-11-30 | — | — | US | disclosed |
| US-6610743-B2 | Central nervous system disorders | GEORGETOWN UNIVERSITY | 2003-08-26 | — | — | US | disclosed |
| US-20020165200-A1 | Bicyclic metabotropic glutamate receptor ligands | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-11-07 | — | — | US | disclosed |
| US-6376532-B2 | NEUROTRANSMITTER | GEORGETOWN UNIVERSITY | 2002-04-23 | — | — | US | disclosed |
| US-20010018429-A1 | Neurotransmitter | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2001-08-30 | — | — | US | disclosed |
| US-6204292-B1 | TREATMENT OF NEUROLOGICAL, NEURODEGENERATIVE, PSYCHIATRIC AND PSYCHOLOGICAL DISORDERS. | GEORGETOWN UNIVERSITY | 2001-03-20 | — | — | US | disclosed |
| EP-1000015-A1 | BICYCLIC METABOTROPIC GLUTAMATE RECEPTOR LIGANDS | GEORGETOWN UNIVERSITY (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999003822-A9 | BICYCLIC METABOTROPIC GLUTAMATE RECEPTOR LIGANDS | UNIV GEORGETOWN (US) | 1999-04-29 | — | — | WO | disclosed |
| WO-1999003822-A1 | BICYCLIC METABOTROPIC GLUTAMATE RECEPTOR LIGANDS | GEORGETOWN UNIVERSITY (US) | 1999-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020165200-A1 | Bicyclic metabotropic glutamate receptor ligands | GRM3, GRM1, GRM2 | FOLH1 329/4885GABRR1 51/4885LMNA 4813/4885 |
| US-20010018429-A1 | Neurotransmitter | GRM3, GRM1, GRM2 | FOLH1 427/4885GABRR1 72/4885LMNA 4734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.