Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886938 | 0.80 | XDH (0.48) | XDHSMN1; SMN2HTR2CHTR2BTMIGD3 | |
| SCHEMBL6752564 | 0.72 | XDH (0.44) | XDHSMN1; SMN2HTR2CHTR2BTMIGD3 | |
| SCHEMBL6879951 | 0.72 | XDH (0.42) | XDHSMN1; SMN2HTR2CHTR2BTMIGD3 | |
| SCHEMBL6884998 | 0.71 | GSK3B (0.34) | — | |
| SCHEMBL7111204 | 0.71 | XDH (0.62) | XDHADORA3ADORA2AADORA1 | |
| SCHEMBL1998266 | 0.70 | XDH (0.60) | XDHSMN1; SMN2HTR2CHTR2BTMIGD3 | |
| SCHEMBL7105981 | 0.69 | XDH (0.59) | XDHADORA3ADORA2AADORA1 | |
| SCHEMBL3451451 | 0.68 | LMNA (0.63) | XDHADORA3ADORA2AADORA1 | |
| SCHEMBL28726405 | 0.68 | XDH (0.70) | XDHSMN1; SMN2HTR2CHTR2BTMIGD3 | |
| SCHEMBL6887745 | 0.68 | LMNA (0.31) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411954-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | Pharmasset Limited (BB) | 2004-04-28 | — | — | EP | disclosed |
| WO-2002032920-A2 | MODIFIED NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION | PHARMASSET LIMITED (BB) | 2002-04-25 | — | — | WO | disclosed |