SCHEMBL688253

SCHEMBL688253

COCc1cc(=O)n2[nH]c(C)cc2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 13/20 1.00
ALDH1A1 P00352 7/20 1.00
HSD17B10 Q99714 4/20 1.00
HPGD P15428 3/20 1.00
TDP1 Q9NUW8 4/20 0.68
SMN1; SMN2 Q16637 3/20 0.66
LMNA P02545 1/20 0.59
MAPT P10636 3/20 0.58
CASP1 P29466 1/20 0.57
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
RECQL P46063 2/20 0.56
CXCR2 P25025 1/20 0.56
POLB P06746 1/20 0.55
BLM P54132 1/20 0.55
PDE10A Q9Y233 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL461294 0.75 KDM4E (1.00) KDM4EALDH1A1HSD17B10HPGDTDP1
SCHEMBL7716577 0.69 KDM4E (0.63) KDM4EALDH1A1HSD17B10HPGDTDP1
SCHEMBL31449599 0.69 KDM4E (0.52) KDM4EALDH1A1HSD17B10HPGDTDP1
SCHEMBL1516428 0.68 KDM4E (0.51) KDM4EALDH1A1HSD17B10HPGDTDP1
SCHEMBL25311269 0.67 KDM4E (0.50) KDM4EALDH1A1HSD17B10HPGDTDP1
SCHEMBL7717364 0.64 KDM4E (0.56) KDM4EALDH1A1HSD17B10HPGDTDP1
SCHEMBL8952119 0.64 TDP1 (0.50) KDM4EALDH1A1HSD17B10HPGDTDP1
SCHEMBL7719491 0.62 KDM4E (0.54) KDM4EALDH1A1HSD17B10HPGDTDP1
SCHEMBL31449590 0.62 KDM4E (0.45) KDM4EALDH1A1HSD17B10HPGDTDP1
SCHEMBL25312657 0.61 KDM4E (0.44) KDM4EALDH1A1HSD17B10HPGDTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1002520-B1 Composition for oxidative dying of keratinous fibres and dying process therewith OREAL (FR) 2008-10-29 EP claimed
WO-2007071686-A1 COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, AN OXIDATION BASE AND A PARTICULAR COUPLER L'ORÉAL (FR) 2007-06-28 WO claimed
US-7179301-B2 Dyeing compositions for keratinous fibers containing paraphenylenediamine derivatives with pyrrolidinyl group L'OREAL S.A. (FR) 2007-02-20 US claimed
US-6890362-B2 Oxidation dyeing composition for keratinous fibers and dyeing method using same L'OREAL, S.A. (FR) 2005-05-10 US claimed
EP-0988021-B1 KERATIN FIBRE OXIDATION DYEING COMPOSITION AND DYEING METHOD USING SAME OREAL (FR) 2003-11-12 EP claimed
US-20030009835-A1 Oxidation dyeing composition for keratinous fibres and dyeing method using same L'OREAL S.A. (FR) 2003-01-16 US claimed
US-6395042-B1 OXIDATION BASE, HETEROCYCLIC COUPLERS FOR OXIDATION COLOR DYE L'ORÉAL (FR) 2002-05-28 US claimed
US-6379395-B1 DYEING FOR HAIR DYE L'OREAL S.A. (FR) 2002-04-30 US claimed
EP-0888109-B1 KERATIN FIBRE DYE COMPOSITION CONTAINING PYRAZOLO-PYRIMIDINEOXO COMPOUNDS, USE THEREOF AS DYE COUPLERS, AND DYEING METHODS OREAL (FR) 2000-08-30 EP claimed
US-12133906-B2 Delivery particle THE PROCTER & GAMBLE COMPANY (US) 2024-11-05 US disclosed
EP-3733827-A1 DELIVERY PARTICLES The Procter & Gamble Company (US) 2020-11-04 EP disclosed
EP-2563508-B1 DELIVERY PARTICLE PROCTER & GAMBLE (US) 2019-07-10 EP disclosed
EP-1642563-B1 Method of rapid hair dyeing NOXELL CORP (US) 2019-06-26 EP disclosed
US-20190142714-A1 DELIVERY PARTICLE PROCTER & GAMBLE (US) 2019-05-16 US disclosed
US-20030009835-A1 Oxidation dyeing composition for keratinous fibres and dyeing method using same L'OREAL S.A. (FR) 2003-01-16 US disclosed
EP-1234569-A1 COMPOSITIONS FOR DYEING HORNY FIBERS Lion Corporation (JP) 2002-08-28 EP disclosed
US-6395042-B1 OXIDATION BASE, HETEROCYCLIC COUPLERS FOR OXIDATION COLOR DYE L'ORÉAL (FR) 2002-05-28 US disclosed
US-6379395-B1 DYEING FOR HAIR DYE L'OREAL S.A. (FR) 2002-04-30 US disclosed
US-6281185-B1 SECOND COMPONENT SELECTED FROM THE GROUP CONSISTING OF AN ALKANE OR CYCLOALKANE HAVING 5 TO 7 CARBON ATOMS 3M INNOVATIVE PROPERTIES COMPANY 2001-08-28 US disclosed
US-6179882-B1 OXIDATION COLOR DYES L'OREAL (FR) 2001-01-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12133906-B2 Delivery particle LIPA, CHMP4B, SLC46A1 KDM4E 4662/4885ALDH1A1 1476/4885HSD17B10 859/4885
US-20190142714-A1 DELIVERY PARTICLE LIPA, CHMP4B, SLC46A1 KDM4E 4662/4885ALDH1A1 1476/4885HSD17B10 859/4885
US-20030009835-A1 Oxidation dyeing composition for keratinous fibres and dyeing method using same KRT18, PPOX, NDUFB5 KDM4E 2568/4885ALDH1A1 321/4885HSD17B10 265/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.