Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP12 | P39900 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462005 | 0.87 | MMP12 (0.66) | HPGDSMN1; SMN2L3MBTL1KMT2AMMP12 | |
| SCHEMBL6881336 | 0.86 | HPGD (0.58) | HPGDSMN1; SMN2L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL6450947 | 0.75 | MMP12 (0.65) | HPGDSMN1; SMN2L3MBTL1MMP2MMP8 | |
| SCHEMBL26856936 | 0.75 | HPGD (0.47) | HPGDSMN1; SMN2KMT2AALDH1A1KDM4E | |
| SCHEMBL4209935 | 0.74 | CHEK1 (0.59) | HPGDSMN1; SMN2L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL6451868 | 0.73 | RAB9A (0.54) | HPGDSMN1; SMN2L3MBTL1MMP2MMP8 | |
| SCHEMBL276395 | 0.73 | KMT2A (0.64) | HPGDSMN1; SMN2L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL6450822 | 0.73 | MMP12 (1.00) | HPGDKMT2AMMP2MMP8MMP12 | |
| SCHEMBL13605517 | 0.73 | HPGD (0.70) | HPGDSMN1; SMN2L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL26856993 | 0.72 | HPGD (0.44) | HPGDSMN1; SMN2KMT2AMMP12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | WARNER-LAMBERT COMPANY LLC | 2004-04-15 | — | — | US | claimed |
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | WARNER-LAMBERT COMPANY LLC | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | MMP11, MMP13, CBR1 | HPGD 612/4885SMN1; SMN2 3494/4885L3MBTL1 4717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.