Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27475141 | 1.00 | KMT2A (0.34) | KMT2APOLBMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6876016 | 0.85 | MMP13 (0.40) | KMT2APOLBMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL27475140 | 0.85 | MMP13 (0.40) | KMT2APOLBMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6879623 | 0.84 | MAPT (0.34) | KMT2AMAPTMEN1SIRT2SIRT1 | |
| SCHEMBL6884268 | 0.84 | MAPT (0.35) | KMT2APOLBMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL27551534 | 0.83 | SIRT2 (0.32) | KMT2APOLBMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL4640097 | 0.82 | TDP1 (0.36) | KMT2APOLBMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL27474218 | 0.81 | KMT2A (0.39) | KMT2APOLBMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL4640715 | 0.81 | KMT2A (0.39) | KMT2APOLBMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL27524220 | 0.79 | ITGB3 (0.46) | CNR1CNR2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1171888-C | Substituted purine derivatives, preparation method and application | ���ĵ�˹ҩƷ�¹��ɷ�����˾ | 2004-10-20 | — | — | CN | disclosed |
| US-6747016-B1 | TREATING OSTEOPOROSIS IN WARM-BLOODED ANIMALS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-06-08 | — | — | US | disclosed |
| EP-1196416-B1 | SUBSTITUTED PURINE DERIVATIVES AS INHIBITORS OF CELL ADHESION | AVENTIS PHARMA GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| CN-1371376-A | substituted purine derivatives as cell adhesion inhibitors | AVENTIS PHARMA GMBH (DE) | 2002-09-25 | — | — | CN | disclosed |
| EP-1196416-A1 | SUBSTITUTED PURINE DERIVATIVES AS INHIBITORS OF CELL ADHESION | Aventis Pharma Deutschland GmbH (DE) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001002399-A1 | SUBSTITUTED PURINE DERIVATIVES AS INHIBITORS OF CELL ADHESION | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-01-11 | — | — | WO | disclosed |
| EP-1065208-A1 | Substituted purine derivatives as inhibitors of cell adhesion | Aventis Pharma Deutschland GmbH (DE) | 2001-01-03 | — | — | EP | disclosed |