Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.34 |
| ▸ | ITGAV | P06756 | 4/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805959 | 0.92 | ITGB3 (0.40) | TDP1KMT2APOLBMAPTKDM4E | |
| SCHEMBL27524220 | 0.89 | ITGB3 (0.46) | CNR1CNR2ITGB3ITGAVHRH4 | |
| SCHEMBL4640164 | 0.89 | ITGB3 (0.46) | CNR1CNR2ITGB3ITGAVHRH4 | |
| SCHEMBL6810270 | 0.87 | NPEPPS (0.34) | TDP1SIRT2SIRT1SIRT3CNR1 | |
| SCHEMBL27474218 | 0.84 | KMT2A (0.39) | TDP1SIRT2SIRT1SIRT3KMT2A | |
| SCHEMBL4640715 | 0.84 | KMT2A (0.39) | TDP1SIRT2SIRT1SIRT3KMT2A | |
| SCHEMBL4641013 | 0.84 | ITGB3 (0.34) | SIRT2SIRT1SIRT3KMT2AMAPT | |
| SCHEMBL6884541 | 0.82 | KMT2A (0.34) | TDP1SIRT2SIRT1SIRT3CNR1 | |
| SCHEMBL27475141 | 0.82 | KMT2A (0.34) | TDP1SIRT2SIRT1SIRT3CNR1 | |
| SCHEMBL6805865 | 0.82 | TDP1 (0.41) | TDP1SIRT2SIRT1SIRT3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853084-B1 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AG (DE) | 2008-08-13 | — | — | EP | disclosed |
| US-6723727-B1 | VITRONECTIN RECEPTOR ANTAGONISTS; INHIBITORS OF BONE RESORPTION; OSTEOPOROSIS | HOECHST AKTIENGESELLSCHAFT (DE) | 2004-04-20 | — | — | US | disclosed |
| EP-0853084-A2 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-15 | — | — | EP | disclosed |