SCHEMBL6885604

SCHEMBL6885604

CCC(C)Cc1[c]c2ccccc2cc1

nearest known ligand 0.32

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.32
HTR2C P28335 1/20 0.32
HTR2B P41595 1/20 0.32
TLR8 Q9NR97 2/20 0.31
TLR7 Q9NYK1 1/20 0.31
MCHR1 Q99705 1/20 0.31
LMNA P02545 1/20 0.30
TSHR P16473 1/20 0.30
HTT P42858 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
GPBAR1 Q8TDU6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3672559 0.87 PPARG (0.31) HTR2AHTR2CHTR2B
SCHEMBL6892978 0.84 POLB (0.32)
SCHEMBL4608372 0.84 HTR2A (0.34) HTR2AHTR2CHTR2B
SCHEMBL6894362 0.83
SCHEMBL6893123 0.81 HTR2A (0.33) HTR2AHTR2CHTR2B
SCHEMBL66086 0.77 CYP1A2 (0.39)
SCHEMBL2498870 0.76 ALDH1A1 (0.38) LMNATSHRHTT
SCHEMBL20526185 0.75 SLC6A2 (0.32) TSHR
SCHEMBL258245 0.74 KDM4E (0.33)
SCHEMBL338434 0.74 PRSS1 (0.40) LMNATSHRHTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888262-B1 CYCLOALKYL DERIVATIVES AND THE SOLID-PHASE SYNTHESIS OF SUCH DERIVATIVES BASF AG (DE) 2004-06-02 EP disclosed
US-6521780-B1 Cycloalkylmalonic ester derivatives as potential active substances in the drugs and crop protection; combinatorial chemistry BASF AKTIENGESELLSCHAFT (DE) 2003-02-18 US disclosed
US-6469056-B1 VERY SELECTIVE INHIBITORS OF ENDOTHELIN CONVERTING ENZYME WITH ACTIVITIES IN THE PICOMOLAR RANGE FOR USE AS HYPOTENSIVE AGENTS ABBOTT LABORATORIES 2002-10-22 US disclosed
EP-0906324-B1 CARBOHYDRATE DERIVATIVES AND THEIR SOLID-PHASE SYNTHESIS BASF AG (DE) 2001-08-01 EP disclosed
US-6242583-B1 COUPLING CARBOHYDRATE COMPOUNDS IN PRESENCE OF PROMOTER TO A FUNCTIONALIZED SOLID SUPPORT BASF AKTIENGESELLSCHAFT (DE) 2001-06-05 US disclosed
EP-1023282-A1 NOVEL PHARMACEUTICALLY ACTIVE COMPOUNDS, THEIR PREPARATION AND USE AS ECE-INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 2000-08-02 EP disclosed
WO-1999019320-A1 NOVEL PHARMACEUTICALLY ACTIVE COMPOUNDS, THEIR PREPARATION AND USE AS ECE-INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1999-04-22 WO disclosed
EP-0906324-A1 CARBOHYDRATE DERIVATIVES AND THEIR SOLID-PHASE SYNTHESIS BASF AKTIENGESELLSCHAFT (DE) 1999-04-07 EP disclosed
EP-0888262-A1 CYCLOALKYL DERIVATIVES AND THE SOLID-PHASE SYNTHESIS OF SUCH DERIVATIVES BASF AKTIENGESELLSCHAFT (DE) 1999-01-07 EP disclosed
WO-1997045436-A1 CARBOHYDRATE DERIVATIVES AND THEIR SOLID-PHASE SYNTHESIS BASF AKTIENGESELLSCHAFT (DE) 1997-12-04 WO disclosed
WO-1997034852-A1 CYCLOALKYL DERIVATIVES AND THE SOLID-PHASE SYNTHESIS OF SUCH DERIVATIVES BASF AKTIENGESELLSCHAFT (DE) 1997-09-25 WO disclosed