SCHEMBL6885871

SCHEMBL6885871

O=C(ON1CCNCC1)c1ccncc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.47
KDM4E B2RXH2 2/20 0.46
RAB9A P51151 2/20 0.46
GLA P06280 1/20 0.46
TSHR P16473 1/20 0.46
HSD17B10 Q99714 1/20 0.44
ADRB2 P07550 1/20 0.44
NCF1 P14598 1/20 0.44
PLD1 Q13393 1/20 0.44
SIGMAR1 Q99720 1/20 0.41
CHRNB2 P17787 2/20 0.41
CHRNB4 P30926 2/20 0.41
CHRNA3 P32297 2/20 0.41
CHRNA4 P43681 2/20 0.41
CHRNA7 P36544 1/20 0.41
MKNK1 Q9BUB5 1/20 0.40
MKNK2 Q9HBH9 1/20 0.40
LMNA P02545 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28145054 0.84 KDM4E (0.50) GAAKDM4ERAB9AGLATSHR
SCHEMBL4522298 0.83 SIGMAR1 (0.56) TSHRHSD17B10SIGMAR1CHRNB2CHRNA4
SCHEMBL24120719 0.83 SIGMAR1 (0.56) TSHRHSD17B10SIGMAR1CHRNB2CHRNA4
SCHEMBL27383717 0.81 SIGMAR1 (0.54) TSHRHSD17B10SIGMAR1CHRNB2CHRNA4
SCHEMBL11197360 0.81 CA12 (0.44) RAB9ATSHRHSD17B10SIGMAR1LMNA
SCHEMBL28083939 0.81 SIGMAR1 (0.54) TSHRHSD17B10SIGMAR1CHRNB2CHRNA4
SCHEMBL21467212 0.81 SIGMAR1 (0.54) TSHRHSD17B10SIGMAR1CHRNB2CHRNA4
SCHEMBL29111259 0.80 L3MBTL1 (0.44) KDM4ETSHRHSD17B10PLD1SIGMAR1
SCHEMBL5874652 0.80 LMNA (0.42) RAB9ATSHRHSD17B10SIGMAR1LMNA
SCHEMBL28807789 0.80 HCAR2 (0.38) TSHRHSD17B10ADRB2SIGMAR1CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107820494-A Nuclear receptor modulators 艾伯维公司 2018-03-20 CN disclosed
WO-2004087933-A2 A NOVEL ENCODING METHOD FOR 'ONE-BEAD ONE-COMPOUND' COMBINATORIAL LIBRARIES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2004-10-14 WO disclosed