SCHEMBL6887378

SCHEMBL6887378

O=C(CCCCCCCCCCBr)OC(=O)CCCCCCCCCCCBr

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.43
DGKA P23743 1/20 0.39
TSHR P16473 3/20 0.38
LMNA P02545 4/20 0.37
NFKB1 P19838 1/20 0.36
PMP22 Q01453 1/20 0.36
PAM P19021 2/20 0.35
MAPT P10636 2/20 0.34
FAAH O00519 1/20 0.34
MAPK1 P28482 1/20 0.34
DNM1 Q05193 1/20 0.32
PRSS1 P07477 1/20 0.32
CTSG P08311 1/20 0.32
CTRB1 P17538 1/20 0.32
CMA1 P23946 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19863302 1.00 ALDH1A1 (0.43) ALDH1A1DGKATSHRLMNANFKB1
SCHEMBL14938147 0.97 ALDH1A1 (0.46) ALDH1A1DGKATSHRLMNANFKB1
SCHEMBL28812961 0.89 DGKA (0.57) ALDH1A1DGKATSHRLMNAPAM
SCHEMBL27238986 0.89 DGKA (0.57) ALDH1A1DGKATSHRLMNAPAM
SCHEMBL3173473 0.88 ALDH1A1 (0.48) ALDH1A1DGKATSHRLMNAPRSS1
SCHEMBL25304019 0.85 ALDH1A1 (0.54) ALDH1A1DGKATSHRLMNAPAM
SCHEMBL27277210 0.85 PTGS1 (0.41) ALDH1A1DGKATSHRLMNAPAM
SCHEMBL27895346 0.85 MGAM (0.43) ALDH1A1DGKATSHRLMNAPAM
SCHEMBL4924469 0.81 DGKA (0.38) ALDH1A1DGKATSHRLMNANFKB1
SCHEMBL18009957 0.81 DGKA (0.48) ALDH1A1DGKATSHRLMNAPAM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1126833-A4 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES INC (US) 2004-09-08 EP disclosed
EP-1126833-A2 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2001-08-29 EP disclosed
WO-2000025768-A1 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2000-05-11 WO disclosed