Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 7/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6897038 | 0.94 | PLA2G2A (0.46) | MAPTPOLBPLA2G2ACCR2PLA2G1B | |
| SCHEMBL6694644 | 0.94 | AR (0.45) | MAPTPLA2G2AALDH1A1SMN1; SMN2AR | |
| SCHEMBL6894303 | 0.92 | DRD2 (0.44) | MAPTPOLBPLA2G2APLA2G1BALDH1A1 | |
| SCHEMBL6690879 | 0.92 | DRD2 (0.47) | MAPTPOLBPLA2G2AALDH1A1AR | |
| SCHEMBL6896588 | 0.92 | PLA2G2A (0.44) | MAPTPLA2G2APLA2G1BALDH1A1HPGD | |
| SCHEMBL6885056 | 0.89 | MAPT (0.46) | MAPTPOLBPLA2G2APLA2G1BALDH1A1 | |
| SCHEMBL6898378 | 0.89 | ACMSD (0.39) | MAPTPLA2G2APLA2G1BALDH1A1HPGD | |
| SCHEMBL6892182 | 0.89 | DRD2 (0.43) | MAPTPOLBPLA2G2AALDH1A1GAA | |
| SCHEMBL6694412 | 0.89 | PLA2G2A (0.56) | MAPTPOLBPLA2G2ACCR2PLA2G1B | |
| SCHEMBL6889569 | 0.88 | MAPK8 (0.43) | MAPTPOLBPLA2G2APLA2G1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |