Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.69 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.69 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.69 |
| ▸ | BTK | Q06187 | 1/20 | 0.69 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.69 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.69 |
| ▸ | GPR3 | P46089 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | ILK | Q13418 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7706331 | 0.83 | LCK (0.51) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL31371878 | 0.83 | LCK (0.51) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL9525498 | 0.81 | LCK (0.50) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL14061350 | 0.81 | BTK (1.00) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| Aminomethylamide SCHEMBL27390143 | 0.80 | LCK (0.50) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL30471260 | 0.80 | LCK (0.67) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL14058931 | 0.80 | LCK (0.67) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL1332157 | 0.78 | MAP2K3 (0.50) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL1123696 | 0.77 | KDM4E (0.47) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL15756098 | 0.76 | LCK (0.61) | LCKMAP2K3MAP2K6BTKMAP3K19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884828-B2 | Substituted cinnolines as inhibitors of LRRK2 kinase activity | IMAGO PHARMACEUTICALS, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| US-9884828-B2 | Substituted cinnolines as inhibitors of LRRK2 kinase activity | IMAGO PHARMACEUTICALS, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| US-20150284337-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2015-10-08 | — | — | US | disclosed |
| US-6693114-B2 | N-(4-CHLOROBENZYL)-6-(3-HYDROXY-1-PROPYNYL)-1-7-DIMETHYL-4-OXO-1,4 -DIHYDRO(1,8) NAPHTHYRIDINE-3-CARBOXAMIDE FOR EXAMPLE; INHIBITING VIRAL DNA POLYMERASE; TREATING HERPES VIRUS INFECTIONS | PHARMACIA & UPJOHN COMPANY | 2004-02-17 | — | — | US | disclosed |
| EP-1265873-B1 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | UPJOHN CO (US) | 2003-10-15 | — | — | EP | disclosed |
| US-6624160-B2 | Especially infections of herpes simplex virus type 1, 2, 6, 7, or 8, varicella zoster virus, human cytomegalovirus or epstein-Barr virus; enzyme inhibitors of virus DNA polymerase | PHARMACIA & UPJOHN CO. | 2003-09-23 | — | — | US | disclosed |
| CN-1418214-A | 4-Hydroxy-1, 8-Naphthyridine-3-carboxamides as antiviral agents | UPJOHN CO (US) | 2003-05-14 | — | — | CN | disclosed |
| CN-1406228-A | 4-oxo-1,4-dihydro-3-cinnolinecarboxamides as antiviral agents | UPJOHN CO (US) | 2003-03-26 | — | — | CN | disclosed |
| CN-1398258-A | 4-Hydroxycinnoline-3-carboxamide compounds as antiviral agents | UPJOHN CO (US) | 2003-02-19 | — | — | CN | disclosed |
| CN-1398258-A | 4-Hydroxycinnoline-3-carboxamide compounds as antiviral agents | UPJOHN CO (US) | 2003-02-19 | — | — | CN | disclosed |
| US-20020042397-A1 | 4-hydroxycinnoline-3-carboxyamides as antiviral agents | PHARMACIA & UPJOHN COMPANY | 2002-04-11 | — | — | US | disclosed |
| US-20020019413-A1 | 4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxamides as antiviral agents | PHARMACIA & UPJOHN COMPANY | 2002-02-14 | — | — | US | disclosed |
| US-20020007066-A1 | 4-hydroxy-1,8-naphthyridine-3-carboxamides as antiviral agents | PHARMACIA & UPJOHN COMPANY | 2002-01-17 | — | — | US | disclosed |
| WO-2001081318-A1 | 4-HYDROXYCINNOLINE-3-CARBOXYAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-11-01 | — | — | WO | disclosed |
| WO-2001074816-A1 | 4-OXO-1,4-DIHYDRO[1,8]NAPHTHYRIDINE-3-CARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |
| WO-2001070706-A2 | 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |
| WO-2001070742-A1 | 4-HYDROXY-1,8-NAPHTHYRIDINE-3-CARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042397-A1 | 4-hydroxycinnoline-3-carboxyamides as antiviral agents | HAVCR2, ZC3HAV1, HCFC1 | LCK 4523/4885MAP2K3 4826/4885MAP2K6 4859/4885 |
| US-20150284337-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | LRRK2, PARK7, PINK1 | LCK 472/4885MAP2K3 306/4885MAP2K6 303/4885 |
| US-20020019413-A1 | 4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxamides as antiviral agents | IRF3, ZC3HAV1, EIF2AK2 | LCK 2787/4885MAP2K3 3788/4885MAP2K6 4360/4885 |
| US-20020007066-A1 | 4-hydroxy-1,8-naphthyridine-3-carboxamides as antiviral agents | CNR1, HAVCR2, NR1H4 | LCK 4569/4885MAP2K3 3838/4885MAP2K6 3625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.