Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.51 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.51 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GPR3 | P46089 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 4/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31371878 | 1.00 | LCK (0.51) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| Aminomethylamide SCHEMBL27390143 | 0.89 | LCK (0.50) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL9525498 | 0.83 | LCK (0.50) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL6890781 | 0.83 | LCK (0.69) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL9496321 | 0.81 | LCK (0.77) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL10752890 | 0.81 | PDE10A (0.51) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL9524877 | 0.80 | ADORA3 (0.56) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL16132525 | 0.79 | PDE10A (0.50) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL10532532 | 0.79 | LCK (0.50) | LCKMAP2K3MAP2K6BTKMAP3K19 | |
| SCHEMBL1123696 | 0.79 | KDM4E (0.47) | LCKMAP2K3MAP2K6BTKMAP3K19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884828-B2 | Substituted cinnolines as inhibitors of LRRK2 kinase activity | IMAGO PHARMACEUTICALS, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| US-9757375-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-12 | — | — | US | disclosed |
| US-9757375-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-12 | — | — | US | disclosed |
| US-20150313898-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-05 | — | — | US | disclosed |
| US-20150313898-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-11-05 | — | — | US | disclosed |
| US-20150284337-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2015-10-08 | — | — | US | disclosed |
| US-9073896-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073896-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2015-07-07 | — | — | US | disclosed |
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| US-20140113891-A1 | Compounds that inhibit human DNA ligases and methods of treating cancer | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-04-24 | — | — | US | disclosed |
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |
| US-4160087-A | BACTERICIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1979-07-03 | — | — | US | disclosed |
| US-4156724-A | N-acylamino-alpha-arylacetamido cephalosporins and antibacterial compositions and methods containing them | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1979-05-29 | — | — | US | disclosed |
| US-4005075-A | Penicillins and their preparation | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-01-25 | — | — | US | disclosed |
| US-4003887-A | ANTIMICROBIAL | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-01-18 | — | — | US | disclosed |
| US-3992371-A | BACTERICIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-11-16 | — | — | US | disclosed |
| US-3954733-A | ANTIBIOTIC | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-05-04 | — | — | US | disclosed |
| US-3945995-A | ANTIBIOTICS, PENICILLIN | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1976-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284337-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | LRRK2, PARK7, PINK1 | LCK 472/4885MAP2K3 306/4885MAP2K6 303/4885 |
| US-20150313898-A1 | COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER | LIG1, LIG4, LIG3 | LCK 3131/4885MAP2K3 3383/4885MAP2K6 3184/4885 |
| US-20140113891-A1 | Compounds that inhibit human DNA ligases and methods of treating cancer | LIG1, LIG4, LIG3 | LCK 3131/4885MAP2K3 3383/4885MAP2K6 3184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.