Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 4/20 | 0.68 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.68 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.68 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.68 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.64 |
| ▸ | FADS1 | O60427 | 2/20 | 0.60 |
| ▸ | PLAU | P00749 | 2/20 | 0.59 |
| ▸ | PLAT | P00750 | 2/20 | 0.59 |
| ▸ | F2 | P00734 | 1/20 | 0.59 |
| ▸ | F10 | P00742 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | DHODH | Q02127 | 2/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | TERT | O14746 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4955725 | 0.87 | P2RX1 (0.68) | P2RX1P2RX4P2RX7TMPRSS4KLKB1 | |
| SCHEMBL28596892 | 0.85 | FADS1 (0.71) | P2RX1P2RX4P2RX7TMPRSS4FADS1 | |
| SCHEMBL23303282 | 0.84 | P2RX1 (0.64) | P2RX1P2RX4P2RX7TMPRSS4KLKB1 | |
| SCHEMBL5852388 | 0.83 | KLKB1 (0.72) | P2RX1P2RX4P2RX7TMPRSS4KLKB1 | |
| SCHEMBL8768715 | 0.83 | PTGS1 (0.68) | P2RX1P2RX4P2RX7TMPRSS4KLKB1 | |
| SCHEMBL14885879 | 0.81 | P2RX1 (1.00) | P2RX1P2RX4P2RX7TMPRSS4KLKB1 | |
| SCHEMBL6252378 | 0.81 | P2RX1 (0.58) | P2RX1P2RX4P2RX7TMPRSS4FADS1 | |
| SCHEMBL30697245 | 0.81 | P2RX1 (0.58) | P2RX1P2RX4P2RX7TMPRSS4FADS1 | |
| SCHEMBL330755 | 0.80 | FADS1 (0.77) | P2RX1P2RX4P2RX7TMPRSS4FADS1 | |
| SCHEMBL8672680 | 0.78 | PTGS1 (0.71) | P2RX1P2RX4P2RX7FADS1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263657-B2 | Blocking neurokinins; using a benzene compound containing hydroxy or acetoxy group; antiinflammatory agents | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2012-09-11 | — | — | US | disclosed |
| US-20040259877-A1 | Inhibitors against the production and release of inflammatory cytokines | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259877-A1 | Inhibitors against the production and release of inflammatory cytokines | NFKBIA, IL1B, IKBKB | P2RX1 2316/4885P2RX4 3466/4885P2RX7 1605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.