Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222397 | 0.88 | CHRM1 (0.71) | CHRM1ADAM17 | |
| SCHEMBL17644714 | 0.88 | CHRM1 (0.71) | CHRM1ADAM17 | |
| SCHEMBL2268477 | 0.88 | CHRM1 (0.71) | CHRM1ADAM17 | |
| SCHEMBL6892450 | 0.87 | CHRM1 (0.54) | CHRM1LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2224496 | 0.87 | GAA (0.55) | CHRM1LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6893880 | 0.86 | CHRM1 (0.54) | CHRM1LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6890115 | 0.85 | GAA (0.45) | LMNASMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL6890076 | 0.85 | KCNH2 (0.48) | LMNASMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL6891544 | 0.84 | CHRM1 (0.47) | CHRM1LMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6891970 | 0.83 | GAA (0.49) | LMNASMN1; SMN2KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |