Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12803113 | 0.89 | CHRM1 (0.58) | CHRM1 | |
| SCHEMBL6891034 | 0.85 | CHRM1 (0.65) | CHRM1 | |
| SCHEMBL22212604 | 0.84 | CHRM1 (0.67) | CHRM1 | |
| SCHEMBL6891717 | 0.84 | CHRM1 (0.54) | CHRM1SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL2224496 | 0.83 | GAA (0.55) | CHRM1SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL6892450 | 0.83 | CHRM1 (0.54) | CHRM1SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL6890441 | 0.82 | CHRM1 (0.60) | CHRM1 | |
| SCHEMBL6893880 | 0.82 | CHRM1 (0.54) | CHRM1SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL17656777 | 0.81 | CHRM1 (0.51) | CHRM1SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL6890001 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4EALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |