Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16615807 | 0.83 | NPC1 (0.63) | KMT2AMEN1MAPTSMN1; SMN2LMNA | |
| SCHEMBL6896043 | 0.78 | ALDH1A1 (0.49) | KMT2AMEN1BCHESMN1; SMN2LMNA | |
| SCHEMBL6894849 | 0.76 | MLYCD (0.49) | HSD17B10LMNAALDH1A1TP53HPGD | |
| SCHEMBL3352714 | 0.76 | MLYCD (0.49) | HSD17B10LMNAALDH1A1TP53HPGD | |
| SCHEMBL6887558 | 0.74 | MLYCD (0.48) | HPGD | |
| SCHEMBL6139506 | 0.71 | MLYCD (0.44) | KMT2AMEN1SMN1; SMN2LMNATDP1 | |
| SCHEMBL2206850 | 0.71 | TP53 (0.51) | KMT2ATDP1ALDH1A1TP53HPGD | |
| SCHEMBL5130313 | 0.71 | MLYCD (0.44) | SMN1; SMN2RAB9ATP53HPGD | |
| SCHEMBL7055563 | 0.71 | DHODH (0.56) | MAPTSMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL3349246 | 0.70 | KDM4E (0.45) | HSD17B10LMNAPOLBTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |