Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12803819 | 0.89 | CHRM1 (0.52) | ADAM17CHRM1 | |
| SCHEMBL6890001 | 0.82 | SMN1; SMN2 (0.51) | S1PR1TP53RAB9AKMT2ARXFP1 | |
| SCHEMBL6892258 | 0.81 | GAA (0.56) | TP53RAB9AKMT2ARXFP1LMNA | |
| SCHEMBL6888967 | 0.81 | MAPT (0.57) | RAB9ANPC1KMT2AGAACNR1 | |
| SCHEMBL6892450 | 0.80 | CHRM1 (0.54) | TP53RAB9AKMT2ARXFP1ADAM17 | |
| SCHEMBL6892513 | 0.80 | CHRM1 (0.64) | RAB9ACHRM1 | |
| SCHEMBL6893778 | 0.79 | CHRM1 (0.51) | S1PR1TP53RAB9ANPC1KMT2A | |
| SCHEMBL2224496 | 0.76 | GAA (0.55) | RAB9AKMT2ARXFP1LMNAGAA | |
| SCHEMBL6890076 | 0.76 | KCNH2 (0.48) | TP53RAB9AKMT2ARXFP1USP2 | |
| SCHEMBL6891970 | 0.76 | GAA (0.49) | TSHRTP53RAB9AKMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |