Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 5/20 | 0.42 |
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6890366 | 0.91 | PLA2G2A (0.45) | PLA2G2ALTB4R2PLA2G10PLA2G1BPLA2G5 | |
| SCHEMBL6776818 | 0.90 | PPARG (0.45) | PLA2G2APPARGPLA2G10PLA2G1BPLA2G5 | |
| SCHEMBL5212605 | 0.89 | MAPK8 (0.42) | PLA2G2APPARGAGTR1AGTR2TRPV1 | |
| SCHEMBL6889205 | 0.89 | MAPK8 (0.41) | PLA2G2APPARGPLA2G1BAGTR1AGTR2 | |
| SCHEMBL6896241 | 0.89 | CNR1 (0.42) | PLA2G2APLA2G1BMAPK8 | |
| SCHEMBL6897067 | 0.88 | CNR1 (0.41) | PLA2G2A | |
| SCHEMBL6895127 | 0.88 | CNR1 (0.42) | — | |
| SCHEMBL6895065 | 0.88 | LMNA (0.40) | AGTR1AGTR2 | |
| SCHEMBL6892057 | 0.88 | HSP90AA1 (0.37) | AGTR1AGTR2 | |
| SCHEMBL6888714 | 0.87 | TSPO (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |