SCHEMBL6894024

SCHEMBL6894024

NC(=O)c1ccc(N2CCN(C(=O)c3ccccc3)CC2)nc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.59
SLC6A7 Q99884 3/20 0.59
MAPK1 P28482 1/20 0.59
L3MBTL1 Q9Y468 1/20 0.59
KDM4E B2RXH2 3/20 0.57
CKS1B P61024 1/20 0.56
SKP1 P63208 1/20 0.56
SKP2 Q13309 1/20 0.56
SMO Q99835 1/20 0.56
PARP1 P09874 1/20 0.53
MEN1 O00255 2/20 0.53
KMT2A Q03164 2/20 0.53
CYP1A2 P05177 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
MGLL Q99685 1/20 0.53
POLB P06746 2/20 0.52
HPGD P15428 1/20 0.52
ALOX15 P16050 1/20 0.52
HSD17B10 Q99714 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4536729 0.86 HRH3 (0.55) ALDH1A1SMOPARP1KMT2A
SCHEMBL13115595 0.82 KDM4E (0.67) ALDH1A1SLC6A7MAPK1L3MBTL1KDM4E
SCHEMBL7141331 0.80 HRH3 (0.53) ALDH1A1SMOPARP1MEN1KMT2A
SCHEMBL29475033 0.79 UBE2T (0.71) ALDH1A1KDM4ESMOPARP1POLB
SCHEMBL30289763 0.79 UBE2T (0.71) ALDH1A1KDM4ESMOPARP1POLB
SCHEMBL27739911 0.79 OPRM1 (0.71) ALDH1A1L3MBTL1SMOPARP1
SCHEMBL26297113 0.79 SLC6A7 (0.56) ALDH1A1SLC6A7MAPK1L3MBTL1KDM4E
SCHEMBL4460927 0.79 RAB9A (0.56) ALDH1A1L3MBTL1KDM4ESMOPARP1
SCHEMBL14181741 0.78 GAA (0.52) ALDH1A1MAPK1L3MBTL1KDM4ESMO
SCHEMBL28684931 0.78 CKS1B (0.84) ALDH1A1SLC6A7MAPK1L3MBTL1CKS1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6677452-B1 PREPARED BY REACTING AMINE WITH PYRIDINE SUBSTITUTED WITH HALOGEN AT POSITION 6 AND WITH CARBOXY OR SULFONYL GROUP AT ANOTHER POSITION TO FORM AMIDE OR SULFONAMIDE, DISPLACING HALOGEN WITH DESIRED DIAMINE LION BIOSCIENCE AG (DE) 2004-01-13 US disclosed
EP-1218343-A4 PYRIDINE CARBOXAMIDE OR SULFONAMIDE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2003-06-18 EP disclosed
EP-1218343-A1 PYRIDINE CARBOXAMIDE OR SULFONAMIDE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION Bioscience AG (DE) 2002-07-03 EP disclosed
WO-2001025203-A1 PYRIDINE CARBOXAMIDE OR SULFONAMIDE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2001-04-12 WO disclosed