Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 8/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | PLEC | Q15149 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6894747 | 0.92 | PLA2G2A (0.44) | PLA2G2APLA2G10PLA2G1BPLA2G5EGFR | |
| SCHEMBL6689220 | 0.90 | PLA2G2A (0.47) | PLA2G2APLA2G10PLA2G1BPLA2G5EGFR | |
| SCHEMBL6890366 | 0.89 | PLA2G2A (0.45) | PLA2G2APLA2G10PLA2G1BPLA2G5EGFR | |
| SCHEMBL6774300 | 0.89 | PLA2G2A (0.48) | PLA2G2APLA2G10PLA2G1BPLA2G5MCL1 | |
| SCHEMBL6892544 | 0.88 | MAPT (0.44) | PLA2G2AKDM4EHPGDMEN1KMT2A | |
| SCHEMBL6896741 | 0.87 | PLA2G2A (0.41) | PLA2G2APLA2G10PLA2G1BPLA2G5EGFR | |
| SCHEMBL6894724 | 0.87 | SLC6A3 (0.48) | PLA2G2APLA2G10PLA2G1BPLA2G5EGFR | |
| SCHEMBL6689196 | 0.86 | GAA (0.47) | PLA2G2APLA2G10PLA2G1BPLA2G5KDM4E | |
| SCHEMBL6889571 | 0.86 | PLA2G2A (0.44) | PLA2G2APLA2G10PLA2G1BPLA2G5EGFR | |
| SCHEMBL6888834 | 0.86 | HSP90AA1 (0.41) | PLA2G2APLA2G1BKDM4EHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |