Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6675574 | 0.79 | CA12 (0.34) | TRPV4CA12CA1CA2CA7 | |
| SCHEMBL29671274 | 0.76 | CA12 (0.38) | TRPV4CA12CA1CA2CA7 | |
| SCHEMBL1535900 | 0.76 | CA12 (0.38) | TRPV4CA12CA1CA2CA7 | |
| SCHEMBL28006505 | 0.75 | CES2 (0.33) | TRPV4 | |
| SCHEMBL4206943 | 0.75 | TRPV4 (0.35) | TRPV4 | |
| SCHEMBL6674733 | 0.72 | TRPV4 (0.32) | TRPV4CA12CA1CA2CA7 | |
| SCHEMBL384682 | 0.72 | PKM (0.38) | TRPV4CA12CA1CA2CA7 | |
| SCHEMBL29835220 | 0.72 | PKM (0.38) | TRPV4CA12CA1CA2CA7 | |
| SCHEMBL1541882 | 0.71 | CA1 (0.41) | CA12CA1CA2CA7 | |
| SCHEMBL699765 | 0.71 | CA12 (0.34) | TRPV4CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1126833-A4 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES INC (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-1126833-A2 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | disclosed |