Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011301 | 0.86 | GPR119 (0.46) | TRPA1POLB | |
| SCHEMBL4317148 | 0.86 | KDM4E (0.41) | KDM4ETRPA1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL4328938 | 0.85 | PDGFRB (0.47) | KDM4ETRPA1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL4317802 | 0.84 | MAOA (0.40) | MAOAMAOBKDM4EALDH1A1NPC1 | |
| SCHEMBL7718355 | 0.83 | SLC6A7 (0.38) | MAOAMAOBSMN1; SMN2MAPK1NPC1 | |
| SCHEMBL4145727 | 0.81 | KDM4E (0.47) | KDM4ESMN1; SMN2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL4313498 | 0.77 | TRPA1 (0.37) | KDM4ETRPA1NPC1KMT2AMAPT | |
| SCHEMBL6201938 | 0.77 | TSHR (0.51) | MAOAMAOBSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL15156267 | 0.75 | MEN1 (0.60) | MAOAMAOBKDM4EALDH1A1NPC1 | |
| SCHEMBL4324601 | 0.75 | KDM4E (0.37) | KDM4ESMN1; SMN2ALDH1A1MAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756377-B2 | PIPERAZINYL)-3-(2-(3-(4-MORPHOLINYLMETHYL)PHENOXY)ETHOXY) PYRAZINE DERIVATIVES; FOR PROPHYLAXIS OR TREATMENT OF SEROTONIN-RELATED DISEASES | BIOVITRUM AB (SE) | 2004-06-29 | — | — | US | disclosed |
| EP-1337518-A1 | PIPERAZINYLPYRAZINES COMPOUNDS AS ANTAGONISTS OF SEROTONIN 5-HT2 RECEPTOR | BIOVITRUM AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002040457-A1 | PIPERAZINYLPYRAZINES COMPOUNDS AS ANTAGONISTS OF SEROTONIN 5-HT2 RECEPTOR | BIOVITRUM AB (SE) | 2002-05-23 | — | — | WO | disclosed |