Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CLPP | Q16740 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6895364 | 0.92 | GRIN1 (0.45) | GRIN1GRIN2BCCR2ARKLKB1 | |
| SCHEMBL6897038 | 0.89 | PLA2G2A (0.46) | GRIN1GRIN2BCCR2DRD2TBXA2R | |
| SCHEMBL6690879 | 0.89 | DRD2 (0.47) | ARDRD2TBXA2RPOLBALOX5 | |
| SCHEMBL6775268 | 0.88 | ADRA1D (0.48) | GRIN1GRIN2BCCR2CNR1KLKB1 | |
| SCHEMBL6890338 | 0.87 | MAPT (0.44) | CNR1DRD2TBXA2RPOLBP2RX7 | |
| SCHEMBL6894303 | 0.87 | DRD2 (0.44) | ARDRD2TBXA2RKLKB1KLK1 | |
| SCHEMBL6694145 | 0.87 | KLKB1 (0.46) | GRIN1GRIN2BCCR2ARKLKB1 | |
| SCHEMBL6897098 | 0.86 | CYP19A1 (0.44) | CNR1DRD2TBXA2RPOLBP2RX7 | |
| SCHEMBL6894657 | 0.86 | MAPT (0.42) | GRIN1GRIN2BDRD2TBXA2RPOLB | |
| SCHEMBL6896662 | 0.86 | KLKB1 (0.44) | GRIN1GRIN2BCCR2ARKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |