Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6893709 | 0.94 | MAPT (0.47) | PLA2G2AMAPTPOLBPLA2G1BCCR2 | |
| SCHEMBL6690879 | 0.94 | DRD2 (0.47) | PLA2G2AMAPTPOLBDRD2TBXA2R | |
| SCHEMBL6890338 | 0.92 | MAPT (0.44) | PLA2G2AMAPTPOLBDRD2TBXA2R | |
| SCHEMBL6894303 | 0.92 | DRD2 (0.44) | PLA2G2AMAPTPOLBDRD2TBXA2R | |
| SCHEMBL6897098 | 0.92 | CYP19A1 (0.44) | PLA2G2AMAPTPOLBDRD2TBXA2R | |
| SCHEMBL6894657 | 0.92 | MAPT (0.42) | PLA2G2AMAPTPOLBDRD2TBXA2R | |
| SCHEMBL6892182 | 0.91 | DRD2 (0.43) | PLA2G2AMAPTPOLBDRD2TBXA2R | |
| SCHEMBL6895025 | 0.89 | GRIN1 (0.45) | POLBDRD2TBXA2RP2RX7CCR2 | |
| SCHEMBL6895281 | 0.89 | FAAH (0.44) | MAPTDRD2TBXA2RSLC6A4SLC6A3 | |
| SCHEMBL6890365 | 0.89 | PPARG (0.46) | MAPTDRD2TBXA2RMAPK10GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |