SCHEMBL6895465

SCHEMBL6895465

CCOC(=O)C(CC(C)C)C(N)=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.44
ALDH1A1 P00352 5/20 0.38
HPGD P15428 2/20 0.38
CAD P27708 1/20 0.37
PPID Q08752 1/20 0.36
POLB P06746 2/20 0.36
LMNA P02545 1/20 0.36
HSD17B10 Q99714 1/20 0.36
SLC7A5 Q01650 1/20 0.35
FHIT P49789 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
MAPK1 P28482 1/20 0.35
GAA P10253 2/20 0.34
MGAM O43451 1/20 0.34
SI P14410 1/20 0.34
MGAM2 Q2M2H8 1/20 0.34
SOAT1 P35610 1/20 0.34
MAPT P10636 1/20 0.34
MME P08473 1/20 0.34
MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL335607 0.87 ALDH1A1 (0.43) ALOX15ALDH1A1PPIDPOLBLMNA
SCHEMBL10807025 0.85 ALDH1A1 (0.42) ALOX15ALDH1A1PPIDPOLBLMNA
SCHEMBL4716423 0.84 ALDH1A1 (0.42) ALOX15ALDH1A1HPGDCADPPID
SCHEMBL489304 0.83 MME (0.43) ALOX15ALDH1A1LMNAHSD17B10SLC7A5
SCHEMBL179900 0.81 ALDH1A1 (0.42) ALOX15ALDH1A1HPGDPPIDLMNA
SCHEMBL7624689 0.81 MME (0.42) ALOX15ALDH1A1LMNAHSD17B10SLC7A5
SCHEMBL6896219 0.81 MME (0.50) POLBSLC7A5SMN1; SMN2MME
SCHEMBL6896224 0.81 MME (0.50) POLBSLC7A5SMN1; SMN2MME
SCHEMBL7355293 0.80 ALOX15 (0.50) ALOX15ALDH1A1HPGDCADPOLB
SCHEMBL14859907 0.79 SLC7A5 (0.46) ALDH1A1SLC7A5MAPK1MMETDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1126833-A4 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES INC (US) 2004-09-08 EP claimed
EP-1126833-A2 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2001-08-29 EP claimed
WO-2000025768-A1 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2000-05-11 WO claimed
EP-1150565-A1 THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION bioscience AG (DE) 2001-11-07 EP disclosed
WO-2000045635-A1 THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2000-08-10 WO disclosed