Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8747403 | 0.89 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL335607 | 0.89 | ALDH1A1 (0.43) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL10807025 | 0.86 | ALDH1A1 (0.42) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL489304 | 0.84 | MME (0.43) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL7624689 | 0.83 | MME (0.42) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL6895465 | 0.81 | ALOX15 (0.44) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL26978010 | 0.81 | ALDH1A1 (0.41) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL1458577 | 0.81 | MME (0.49) | ALDH1A1LMNAHSD17B10MGAMGAA | |
| SCHEMBL4142966 | 0.81 | TP53 (0.41) | ALDH1A1LMNAHSD17B10ALOX15MGAM | |
| SCHEMBL27617570 | 0.81 | SOAT1 (0.39) | ALDH1A1LMNAHSD17B10ALOX15MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12077487-B2 | Methods of manufacturing benzoquinoline compounds | AUSPEX PHARMACEUTICALS, INC. (US) | 2024-09-03 | — | — | US | disclosed |
| CN-114456286-B | Catalyst system for olefin polymerization and application thereof | 中国石油化工股份有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-114456290-B | Catalyst system for olefin polymerization and prepolymerized catalyst composition | 中国石油化工股份有限公司 | 2023-07-21 | — | — | CN | disclosed |
| US-20230159546-A1 | NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. | 2023-05-25 | — | — | US | disclosed |
| US-20230060294-A1 | METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS | AUSPEX PHARMACEUTICALS LLC | 2023-03-02 | — | — | US | disclosed |
| CN-114456286-A | Catalyst system for olefin polymerization and use thereof | 中国石油化工股份有限公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456290-A | Catalyst system for olefin polymerization and prepolymerized catalyst composition | 中国石油化工股份有限公司 | 2022-05-10 | — | — | CN | disclosed |
| US-20200347008-A1 | METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS | AUSPEX PHARMACEUTICALS, INC. | 2020-11-05 | — | — | US | disclosed |
| US-20200331846-A1 | METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS | AUSPEX PHARMACEUTICALS INC (US) | 2020-10-22 | — | — | US | disclosed |
| US-20200331846-A1 | METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS | AUSPEX PHARMACEUTICALS INC (US) | 2020-10-22 | — | — | US | disclosed |
| EP-1248612-B1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-02-27 | — | — | EP | disclosed |
| WO-2007062370-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |
| EP-1248612-A4 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2005-09-07 | — | — | EP | disclosed |
| US-6525036-B2 | Treating post-menopausal osteoporosis. | MERCK & CO., INC. | 2003-02-25 | — | — | US | disclosed |
| US-6509312-B1 | To impart a very natural fruity note | FIRMENICH SA (CH) | 2003-01-21 | — | — | US | disclosed |
| EP-1248612-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2002-10-16 | — | — | EP | disclosed |
| US-20020052378-A1 | Novel compounds and compositions as protease inhibitors | Celera Corporation | 2002-05-02 | — | — | US | disclosed |
| WO-2001049288-A9 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2001-10-25 | — | — | WO | disclosed |
| WO-2001049288-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-07-12 | — | — | WO | disclosed |
| US-4116674-A | Process of severely damaging or killing unwanted plants with pyrimidine compounds | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1978-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200331846-A1 | METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS | SLC18A2, SLC18A1, SLC6A2 | ALDH1A1 816/4885LMNA 2209/4885HSD17B10 614/4885 |
| US-20200347008-A1 | METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS | SLC18A2, SLC18A1, SLC6A2 | ALDH1A1 816/4885LMNA 2209/4885HSD17B10 614/4885 |
| US-20230159546-A1 | NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ACE, ACE2, REN | ALDH1A1 353/4885LMNA 3711/4885HSD17B10 744/4885 |
| US-12077487-B2 | Methods of manufacturing benzoquinoline compounds | SLC18A2, SLC18A1, SLC6A2 | ALDH1A1 816/4885LMNA 2209/4885HSD17B10 614/4885 |
| US-20020052378-A1 | Novel compounds and compositions as protease inhibitors | SERPINB1, CTRL, SPINT2 | ALDH1A1 1987/4885LMNA 2284/4885HSD17B10 1174/4885 |
| US-20230060294-A1 | METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS | SLC18A2, SLC18A1, SLC6A2 | ALDH1A1 816/4885LMNA 2209/4885HSD17B10 614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.