Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | RARB | P10826 | 2/20 | 0.33 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SPNS2 | Q8IVW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6901883 | 0.96 | HSD11B1 (0.34) | HSD11B1KDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL6903349 | 0.92 | MEN1 (0.32) | S1PR1MEN1KMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7723032 | 0.88 | EDNRB (0.30) | — | |
| Hydrochloric Acid SCHEMBL6903331 | 0.83 | KDM4E (0.30) | KDM4EHSD17B10ALDH1A1HPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6902904 | 0.82 | KDM4E (0.33) | KDM4ESLC6A2SLC6A4HSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6897842 | 0.80 | RARB (0.33) | HSD11B1KDM4ERAB9ATNNC1S1PR1 | |
| Hydrochloric Acid SCHEMBL6902674 | 0.79 | HTR2A (0.38) | HSD11B1KDM4ERAB9AS1PR1S1PR4 | |
| Hydrochloric Acid SCHEMBL6895555 | 0.77 | HSD11B1 (0.35) | HSD11B1KDM4ERAB9ATNNC1S1PR1 | |
| Hydrochloric Acid SCHEMBL6898012 | 0.76 | S1PR5 (0.32) | KDM4ES1PR4S1PR5SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL6903351 | 0.76 | HSD11B1 (0.32) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |