Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6903366 | 0.96 | BRS3 (0.36) | MEN1KMT2AMAPTRAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL6903467 | 0.92 | GPR88 (0.38) | MEN1KMT2AMAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6902388 | 0.87 | NPC1 (0.36) | KMT2AMAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6903050 | 0.86 | HTR2A (0.38) | HTR2ADRD2SLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL6899139 | 0.82 | SYK (0.40) | MEN1KMT2AMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6901173 | 0.82 | BRS3 (0.36) | KMT2AMAPTRAB9AALDH1A1HSD11B1 | |
| Hydrochloric Acid SCHEMBL6904743 | 0.80 | ALDH1A1 (0.37) | KMT2AMAPTRAB9AALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL6904678 | 0.80 | ALDH1A1 (0.33) | MEN1KMT2AMAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6895494 | 0.79 | HSD11B1 (0.35) | HTR2ADRD2SLC6A2HTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL6897842 | 0.79 | RARB (0.33) | HTR2ADRD2SLC6A2HTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |