SCHEMBL6895755

SCHEMBL6895755

Nc1ccc(Cl)c(N=C2NCCN2)c1Cl

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.31
AHR P35869 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL10876923 0.98 ALDH1A1 (0.31) NOTUMAHR
Hydrochloric Acid SCHEMBL10818417 0.87
SCHEMBL10863938 0.79 NOTUM (0.31) NOTUM
SCHEMBL8891031 0.79 GAA (0.33)
Clonidine SCHEMBL5982 0.75 MAPT (0.36) AHR
Clonidine SCHEMBL1369983 0.75 MAPT (0.36) AHR
SCHEMBL10607540 0.75 GAA (0.30)
SCHEMBL10973840 0.75 CD44 (0.33)
Clonidine SCHEMBL10972183 0.73 ADRA2A (0.36) AHR
Clonidine SCHEMBL40751 0.73 ADRA2A (0.36) AHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0081924-B1 TOPICAL COMPOSTIONS FOR LOWERING INTRAOCULAR PRESSURE ALCON LABORATORIES, INC. (US) 1986-02-19 EP claimed
US-6747051-B2 BLADDER UROGENITAL DISORDERS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-06-08 US disclosed
CN-1471514-A Novel M-amino-phenylimino-imidazolidone derivatives for treating urinary incontinence ���ָ��Ӣ��ķ�������Ϲ�˾ 2004-01-28 CN disclosed
US-20030158420-A1 m-Amino-phenylimino-imidazolidine derivatives for treaing urinary incontinence BOEHRINGER INGELHEIM PHARMA GMBH CO. KG (DE) 2003-08-21 US disclosed
US-6602897-B2 For example, 2-((2-bromo-3-chloro-5-dimethylamino-6-methylphenyl)imino)imid azolidine BOEHRINGER INGELHEIM PHARMA KG (DE) 2003-08-05 US disclosed
EP-1328517-A2 NOVEL M-AMINO-PHENYLIMINO-IMIDAZOLIDINE DERIVATIVES FOR TREATING URINARY INCONTINENCE Boehringer Ingelheim Pharma KG (DE) 2003-07-23 EP disclosed
US-20020161031-A1 m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2002-10-31 US disclosed
WO-2002032876-A2 NOVEL M-AMINO-PHENYLIMINO-IMIDAZOLIDINE DERIVATIVES FOR TREATING URINARY INCONTINENCE BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2002-04-25 WO disclosed
EP-0070084-A2 Imidazoline derivatives BEECHAM GROUP PLC (GB) 1983-01-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020161031-A1 m-amino-phenylimino-imidazolidine derivatives for treating urinary incontinence RXFP1, RXFP3, PRMT1 NOTUM 3633/4885AHR 951/4885
US-20030158420-A1 m-Amino-phenylimino-imidazolidine derivatives for treaing urinary incontinence HRH2, RXFP3, AREG NOTUM 3669/4885AHR 1654/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.