Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6894500 | 0.92 | PTGDR2 (0.39) | SLC6A3HSP90AA1HSP90B1ALDH1A1KDM4E | |
| SCHEMBL6887896 | 0.90 | MAPT (0.44) | SLC6A3SLC6A4DRD2TBXA2RABCB1 | |
| SCHEMBL6897905 | 0.90 | DRD2 (0.43) | SLC6A3SLC6A4DRD2TBXA2RHSP90AA1 | |
| SCHEMBL6889740 | 0.89 | SLC6A4 (0.41) | SLC6A3SLC6A4DRD2TBXA2RABCB1 | |
| SCHEMBL6771780 | 0.89 | IKBKB (0.37) | ABCB1MIF | |
| SCHEMBL6690879 | 0.88 | DRD2 (0.47) | SLC6A3SLC6A4DRD2TBXA2RALDH1A1 | |
| SCHEMBL6894724 | 0.88 | SLC6A3 (0.48) | SLC6A3SLC6A4DRD2TBXA2RALDH1A1 | |
| SCHEMBL6889876 | 0.88 | MAPK8 (0.44) | SLC6A3SLC6A4DRD2TBXA2RALDH1A1 | |
| SCHEMBL6895138 | 0.87 | HSP90AA1 (0.43) | SLC6A3SLC6A4DRD2TBXA2RHSP90AA1 | |
| SCHEMBL6895819 | 0.86 | GRIN1 (0.50) | SLC6A3SLC6A4DRD2TBXA2RALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |