Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 10/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.50 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896480 | 0.93 | GRIN1 (0.45) | GRIN1GRIN2BNOX4RXFP1ALDH1A1 | |
| SCHEMBL6776013 | 0.89 | GRIN1 (0.49) | GRIN1GRIN2BNOX4ALDH1A1TSHR | |
| SCHEMBL6887896 | 0.88 | MAPT (0.44) | SLC6A4SLC6A3ALDH1A1DRD2TBXA2R | |
| SCHEMBL6897905 | 0.87 | DRD2 (0.43) | SLC6A4SLC6A3ALDH1A1DRD2TBXA2R | |
| SCHEMBL6889740 | 0.86 | SLC6A4 (0.41) | SLC6A4SLC6A3ALDH1A1DRD2TBXA2R | |
| SCHEMBL6896346 | 0.86 | SLC6A3 (0.41) | SLC6A4SLC6A3ALDH1A1DRD2TBXA2R | |
| SCHEMBL6891000 | 0.86 | GRIN1 (0.43) | GRIN1GRIN2BNOX4RXFP1ALDH1A1 | |
| SCHEMBL6690879 | 0.86 | DRD2 (0.47) | SLC6A4SLC6A3ALDH1A1DRD2TBXA2R | |
| SCHEMBL6692711 | 0.86 | ALDH1A1 (0.46) | GRIN1GRIN2BNOX4RXFP1ALDH1A1 | |
| SCHEMBL6889876 | 0.85 | MAPK8 (0.44) | SLC6A4SLC6A3ALDH1A1DRD2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |