Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5118350 | 0.90 | POLB (0.42) | GAAKDM4EALDH1A1MAPTSSTR5 | |
| SCHEMBL691322 | 0.87 | SSTR5 (0.38) | KDM4ESSTR5MEN1KMT2A | |
| SCHEMBL5124004 | 0.87 | HCRTR1 (0.42) | KDM4EALDH1A1MAPTSSTR5SCN9A | |
| SCHEMBL689686 | 0.83 | SSTR5 (0.42) | GAAKDM4EALDH1A1MAPTSSTR5 | |
| SCHEMBL689162 | 0.82 | SSTR5 (0.41) | GAAKDM4EALDH1A1MAPTSSTR5 | |
| SCHEMBL5119234 | 0.80 | SCN9A (0.43) | KDM4EALDH1A1SCN9AMEN1POLB | |
| SCHEMBL689665 | 0.78 | MAPT (0.41) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL690226 | 0.78 | ALDH1A1 (0.43) | GAAKDM4EALDH1A1SSTR5MEN1 | |
| SCHEMBL5114802 | 0.77 | SCN9A (0.46) | SCN9APOLBSMN1; SMN2 | |
| SCHEMBL690623 | 0.76 | RARG (0.41) | GAAKDM4EALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |